Microglia dynamics in adolescent traumatic brain injury

Eric Eyolfson, Asher Khan, Richelle Mychasiuk, Alexander W. Lohman

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Repetitive, mild traumatic brain injuries (RmTBIs) are increasingly common in adolescents and encompass one of the largest neurological health concerns in the world. Adolescence is a critical period for brain development where RmTBIs can substantially impact neurodevelopmental trajectories and life-long neurological health. Our current understanding of RmTBI pathophysiology suggests key roles for neuroinflammation in negatively regulating neural health and function. Microglia, the brain’s resident immune population, play important roles in brain development by regulating neuronal number, and synapse formation and elimination. In response to injury, microglia activate to inflammatory phenotypes that may detract from these normal homeostatic, physiological, and developmental roles. To date, however, little is known regarding the impact of RmTBIs on microglia function during adolescent brain development. This review details key concepts surrounding RmTBI pathophysiology, adolescent brain development, and microglia dynamics in the developing brain and in response to injury, in an effort to formulate a hypothesis on how the intersection of these processes may modify long-term trajectories.

Original languageEnglish
Article number326
Number of pages19
JournalJournal of Neuroinflammation
Volume17
Issue number1
DOIs
Publication statusPublished - 29 Oct 2020

Keywords

  • Brain maturation
  • Complement cascade
  • Glia
  • Pathophysiology
  • Synaptic pruning
  • White matter

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