Microfluidics for the production of nanomedicines: Considerations for polymer and lipid-based systems

Sarah Streck, Linda Hong, Ben J. Boyd, Arlene McDowell

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Background: Microfluidics is becoming increasingly of interest as a superior technique for the synthesis of nanoparticles, particularly for their use in nanomedicine. In microfluidics, small volumes of liquid reagents are rapidly mixed in a microchannel in a highly controlled manner to form nanoparticles with tunable and reproducible structure that can be tailored for drug delivery. Both polymer and lipid-based nanoparticles are utilized in nanomedicine and both are amenable to preparation by microfluidic approaches. 

Aim: Therefore, the purpose of this review is to collect the current state of knowledge on the microfluidic preparation of polymeric and lipid nanoparticles for pharmaceutical applications, including descriptions of the main synthesis modalities. Of special interest are the mechanisms involved in nanoparticle formation and the options for surface functionalisa-tion to enhance cellular interactions. 

Conclusion: The review will conclude with the identification of key considerations for the production of polymeric and lipid nanoparticles using microfluidic approaches.

Original languageEnglish
Pages (from-to)423-443
Number of pages21
JournalPharmaceutical Nanotechnology
Volume7
Issue number6
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • Droplets
  • Lipid
  • Liposomes
  • Microfluidics
  • Nanoparticles
  • PLGA polymer

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