Microfluidics for sperm analysis and selection

Reza Nosrati, Percival J. Graham, Biao Zhang, Jason Riordon, Alexander Lagunov, Thomas G. Hannam, Carlos Escobedo, Keith Jarvi, David Sinton

Research output: Contribution to journalReview ArticleResearchpeer-review

49 Citations (Scopus)

Abstract

Infertility is a growing global health issue with far-reaching socioeconomic implications. A downward trend in male fertility highlights the acute need for affordable and accessible diagnosis and treatment. Assisted reproductive technologies are effective in treating male infertility, but their success rate has plateaued at ~33% per cycle. Many emerging opportunities exist for microfluidics-a mature technology in other biomedical areas-in male infertility diagnosis and treatment, and promising microfluidic approaches are under investigation for addressing male infertility. Microfluidic approaches can improve our fundamental understanding of sperm motion, and developments in microfluidic devices that use microfabrication and sperm behaviour can aid semen analysis and sperm selection. Many burgeoning possibilities exist for engineers, biologists, and clinicians to improve current practices for infertility diagnosis and treatment. The most promising avenues have the potential to improve medical practice, moving innovations from research laboratories to clinics and patients in the near future.

Original languageEnglish
Pages (from-to)707-730
Number of pages24
JournalNature Reviews Urology
Volume14
Issue number12
DOIs
Publication statusPublished - 1 Dec 2017
Externally publishedYes

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