Microfluidics devices to investigate blood cell dynamics during thrombus formation driven by shear-gradients on microstenosis

Francisco J. Tovar-Lopez, Thach Nguyen, Mahyar Nasabi, Vijay Sivan, Arnan Mitchell, Warwick S. Nesbitt

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther

Abstract

We report on a microfluidic experimental platform and a computational fluid dynamics model to study blood cell dynamics at micro-scale stenoses where local strain-rate microgradients trigger platelet aggregation. The manner in which stenotic flow affects blood cell mass transport at physiological flow rates; and how this modulates platelet aggregation, remains unexplored. We present the design and experimental validation of a microfluidic device that incorporates asymmetric flow focusing of several fluidic streams to study the hemodynamic variables promoting platelet aggregation at shear-gradient mechanisms as well as a computational model to investigate local forces enhancing platelet transport.

Original languageEnglish
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
Place of PublicationSan Diego CA USA
PublisherChemical and Biological Microsystems Society
Pages357-359
Number of pages3
ISBN (Electronic)9780979806476
Publication statusPublished - 1 Jan 2014
Externally publishedYes
EventInternational Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014) - San Antonio, United States of America
Duration: 26 Oct 201430 Oct 2014
Conference number: 18th

Conference

ConferenceInternational Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014)
Abbreviated titleMicroTAS 2014
CountryUnited States of America
CitySan Antonio
Period26/10/1430/10/14

Keywords

  • Blood clotting
  • Cfd
  • Microfluidics
  • Shear gradients
  • Volume of fluid

Cite this

Tovar-Lopez, F. J., Nguyen, T., Nasabi, M., Sivan, V., Mitchell, A., & Nesbitt, W. S. (2014). Microfluidics devices to investigate blood cell dynamics during thrombus formation driven by shear-gradients on microstenosis. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 357-359). San Diego CA USA: Chemical and Biological Microsystems Society.
Tovar-Lopez, Francisco J. ; Nguyen, Thach ; Nasabi, Mahyar ; Sivan, Vijay ; Mitchell, Arnan ; Nesbitt, Warwick S. / Microfluidics devices to investigate blood cell dynamics during thrombus formation driven by shear-gradients on microstenosis. 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. San Diego CA USA : Chemical and Biological Microsystems Society, 2014. pp. 357-359
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title = "Microfluidics devices to investigate blood cell dynamics during thrombus formation driven by shear-gradients on microstenosis",
abstract = "We report on a microfluidic experimental platform and a computational fluid dynamics model to study blood cell dynamics at micro-scale stenoses where local strain-rate microgradients trigger platelet aggregation. The manner in which stenotic flow affects blood cell mass transport at physiological flow rates; and how this modulates platelet aggregation, remains unexplored. We present the design and experimental validation of a microfluidic device that incorporates asymmetric flow focusing of several fluidic streams to study the hemodynamic variables promoting platelet aggregation at shear-gradient mechanisms as well as a computational model to investigate local forces enhancing platelet transport.",
keywords = "Blood clotting, Cfd, Microfluidics, Shear gradients, Volume of fluid",
author = "Tovar-Lopez, {Francisco J.} and Thach Nguyen and Mahyar Nasabi and Vijay Sivan and Arnan Mitchell and Nesbitt, {Warwick S.}",
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Tovar-Lopez, FJ, Nguyen, T, Nasabi, M, Sivan, V, Mitchell, A & Nesbitt, WS 2014, Microfluidics devices to investigate blood cell dynamics during thrombus formation driven by shear-gradients on microstenosis. in 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. Chemical and Biological Microsystems Society, San Diego CA USA, pp. 357-359, International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2014), San Antonio, United States of America, 26/10/14.

Microfluidics devices to investigate blood cell dynamics during thrombus formation driven by shear-gradients on microstenosis. / Tovar-Lopez, Francisco J.; Nguyen, Thach; Nasabi, Mahyar; Sivan, Vijay; Mitchell, Arnan; Nesbitt, Warwick S.

18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. San Diego CA USA : Chemical and Biological Microsystems Society, 2014. p. 357-359.

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther

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AU - Tovar-Lopez, Francisco J.

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AU - Mitchell, Arnan

AU - Nesbitt, Warwick S.

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AB - We report on a microfluidic experimental platform and a computational fluid dynamics model to study blood cell dynamics at micro-scale stenoses where local strain-rate microgradients trigger platelet aggregation. The manner in which stenotic flow affects blood cell mass transport at physiological flow rates; and how this modulates platelet aggregation, remains unexplored. We present the design and experimental validation of a microfluidic device that incorporates asymmetric flow focusing of several fluidic streams to study the hemodynamic variables promoting platelet aggregation at shear-gradient mechanisms as well as a computational model to investigate local forces enhancing platelet transport.

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KW - Cfd

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KW - Shear gradients

KW - Volume of fluid

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Tovar-Lopez FJ, Nguyen T, Nasabi M, Sivan V, Mitchell A, Nesbitt WS. Microfluidics devices to investigate blood cell dynamics during thrombus formation driven by shear-gradients on microstenosis. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. San Diego CA USA: Chemical and Biological Microsystems Society. 2014. p. 357-359