Microfluidic valve geometries and possibilities for flow switching in gas chromatography

Philip Marriott, Graham Eyres, Sylvia Urban, Christian Ruhle

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review


Classical two-dimensional separations in gas chromatography (GC) require switching systems to transfer the flow stream of carrier gas from the first to second dimension. This can be accomplished by valve systems, but is more suitably effected by pneumatic flow switching, such as the Deansa?? switch method. Recent developments in microfluidics and related micro-technologies should make gas phase switching much more effective. The capillary flow technology platform of Agilent Technologies exemplifies recent developments introduced to GC. Thus various Deansa?? switch pressure balanced devices, stream splitters, and column couplings bring new capabilities to analytical GC. We are uniquely placed to take advantage of the new devices, owing to our development of advanced operational methods in GC which can make use of microfluidic capillary couplings, and novel cryogenic approaches that deliver performance previously impossible with conventional methods. Multidimensional chromatographic flow switching to isolate pure compounds from complex mixtures suggests many potential applications for enhanced chemical analysis. Multiple dimensions of analysis, integrating capabilities for gas chromatography separations with different spectroscopic detection methods for chemical identification of isolated chemical species (including mass spectrometry, nuclear magnetic resonance and Fourier transform infrared) can be proposed. Applications in the essential oils and petrochemical area will be outlined.
Original languageEnglish
Title of host publicationBiomedical Applications of Micro- and Nanoengineering IV and Complex Systems
EditorsDan V Nicolau, Guy Metcalfe
Place of PublicationUSA
Pages72700G-1 - 72700G-11
Number of pages11
ISBN (Print)9780819475220
Publication statusPublished - 2009
Externally publishedYes
EventBiomedical Applications of Micro- and Nanoengineering IV and Complex Systems 2009 - Melbourne Australia, USA
Duration: 1 Jan 2009 → …


ConferenceBiomedical Applications of Micro- and Nanoengineering IV and Complex Systems 2009
Period1/01/09 → …

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