Abstract
A microfluidics approach to synthesize core-shell nanocarriers with high pH tunability is described. The sacrificial shell protects the core layer with the drugs and prevents their release in the severe pH conditions of the gastrointestinal tract, while allowing for drug release in the proximity of a tumor. The proposed nanoparticulate drug-delivery system is designed for the oral administration of cancer therapeutics.
| Original language | English |
|---|---|
| Pages (from-to) | 4134-4141 |
| Number of pages | 8 |
| Journal | Advanced Materials |
| Volume | 28 |
| Issue number | 21 |
| DOIs | |
| Publication status | Published - 1 Jun 2016 |
Keywords
- Cancer therapy
- Core-shell nanoparticles
- Drug delivery
- Microfluidics platform
- Stimuli-responsive release
Cite this
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Microfluidic manipulation of core/shell nanoparticles for oral delivery of chemotherapeutics : A new treatment approach for colorectal cancer. / Hasani-Sadrabadi, Mohammad Mahdi; Taranejoo, Shahrouz; Dashtimoghadam, Erfan; Bahlakeh, Ghasem; Majedi, Fatemeh Sadat; Vandersarl, Jules John; Janmaleki, Mohsen; Sharifi, Fatemeh; Bertsch, Arnaud; Hourigan, Kerry; Tayebi, Lobat; Renaud, Philippe; Jacob, Karl I.
In: Advanced Materials, Vol. 28, No. 21, 01.06.2016, p. 4134-4141.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Microfluidic manipulation of core/shell nanoparticles for oral delivery of chemotherapeutics
T2 - A new treatment approach for colorectal cancer
AU - Hasani-Sadrabadi, Mohammad Mahdi
AU - Taranejoo, Shahrouz
AU - Dashtimoghadam, Erfan
AU - Bahlakeh, Ghasem
AU - Majedi, Fatemeh Sadat
AU - Vandersarl, Jules John
AU - Janmaleki, Mohsen
AU - Sharifi, Fatemeh
AU - Bertsch, Arnaud
AU - Hourigan, Kerry
AU - Tayebi, Lobat
AU - Renaud, Philippe
AU - Jacob, Karl I.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - A microfluidics approach to synthesize core-shell nanocarriers with high pH tunability is described. The sacrificial shell protects the core layer with the drugs and prevents their release in the severe pH conditions of the gastrointestinal tract, while allowing for drug release in the proximity of a tumor. The proposed nanoparticulate drug-delivery system is designed for the oral administration of cancer therapeutics.
AB - A microfluidics approach to synthesize core-shell nanocarriers with high pH tunability is described. The sacrificial shell protects the core layer with the drugs and prevents their release in the severe pH conditions of the gastrointestinal tract, while allowing for drug release in the proximity of a tumor. The proposed nanoparticulate drug-delivery system is designed for the oral administration of cancer therapeutics.
KW - Cancer therapy
KW - Core-shell nanoparticles
KW - Drug delivery
KW - Microfluidics platform
KW - Stimuli-responsive release
UR - http://www.scopus.com/inward/record.url?scp=84962595018&partnerID=8YFLogxK
U2 - 10.1002/adma.201502697
DO - 10.1002/adma.201502697
M3 - Article
VL - 28
SP - 4134
EP - 4141
JO - Advanced Materials
JF - Advanced Materials
SN - 0935-9648
IS - 21
ER -