Microfluidic manipulation of core/shell nanoparticles for oral delivery of chemotherapeutics: A new treatment approach for colorectal cancer

Mohammad Mahdi Hasani-Sadrabadi, Shahrouz Taranejoo, Erfan Dashtimoghadam, Ghasem Bahlakeh, Fatemeh Sadat Majedi, Jules John Vandersarl, Mohsen Janmaleki, Fatemeh Sharifi, Arnaud Bertsch, Kerry Hourigan, Lobat Tayebi, Philippe Renaud, Karl I. Jacob

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Abstract

A microfluidics approach to synthesize core-shell nanocarriers with high pH tunability is described. The sacrificial shell protects the core layer with the drugs and prevents their release in the severe pH conditions of the gastrointestinal tract, while allowing for drug release in the proximity of a tumor. The proposed nanoparticulate drug-delivery system is designed for the oral administration of cancer therapeutics.

Original languageEnglish
Pages (from-to)4134-4141
Number of pages8
JournalAdvanced Materials
Volume28
Issue number21
DOIs
Publication statusPublished - 1 Jun 2016

Keywords

  • Cancer therapy
  • Core-shell nanoparticles
  • Drug delivery
  • Microfluidics platform
  • Stimuli-responsive release

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