Microfluidic devices for developing tissue scaffolds

Lien T. Chau, Jessica E. Frith, Richard J. Mills, Donna J. Menzies, Drew M Titmarsh, Justin J. Cooper-White

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

1 Citation (Scopus)

Abstract

This chapter begins by outlining the key hurdles that currently exist in terms of achieving directed tissue genesis, in vitro and in vivo, from available mature, progenitor and stem cell sources. The chapter then Sugiura et al., 2005 proceeds to describe how microfluidic device platforms can provide the required insights to overcome these hurdles to clinical translation, including the optimization of soluble factor provision to enhance cell expansion and differentiation outcomes, the impacts of pore architecture and surface engineering on scaffold colonization, and the biophysical needs of cells when creating three dimensional artificial vascular pedicles for improved scaffold vascularization post-implantation.

Original languageEnglish
Title of host publicationMicrofluidic Devices for Biomedical Applications
EditorsXiujun (James) Li, Yu Zhou
Place of PublicationCambridge, UK
PublisherElsevier
Chapter10
Pages363-387
Number of pages25
Volume61
ISBN (Electronic)9780857097040
ISBN (Print)9780857096975
DOIs
Publication statusPublished - Oct 2013
Externally publishedYes

Keywords

  • Microdevices
  • Scaffolds
  • Stem cells
  • Tissue engineering
  • Tissue genesis

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