TY - JOUR
T1 - Microbiologic follow-up study in adult bronchiectasis
AU - King, Paul Thomas
AU - Holdsworth, Stephen Roger
AU - Freezer, Nicholas
AU - Villanueva, Elmer Virgil
AU - Holmes, Peter W
PY - 2007
Y1 - 2007
N2 - There is minimal published longitudinal data about pathogenic microorganisms in adults with bronchiectasis. Therefore a study was undertaken to assess the microbiologic profile over time in bronchiectasis. A prospective study of clinical and microbiologic outcomes was performed. Subjects were assessed by a respiratory physician and sputum sample were collected for analysis. Subjects were followed up and had repeat assessment performed. Eighty-nine subjects were followed up for a period of 5.7+/-3.6 years. On initial assessment the two most common pathogens isolated were Haemophilus influenzae (47 ) and Pseudomonas aeruginosa (12 ) whilst 21 had no pathogens isolated. On follow-up review results were similar (40 H. influenzae, 18 P. aeruginosa and 26 no pathogens). The prevalence of antibiotic resistance of isolates increased from 13 to 30 . Analysis of a series of H. influenzae isolates showed they were nearly all nontypeable and all were different subtypes. Subjects with no pathogens isolated from their sputum had the mildest disease, while subjects with P. aeruginosa had the most severe bronchiectasis. Many subjects with bronchiectasis are colonized with the same bacterium over an average follow-up of 5 years. Different pathogens are associated with different patterns of clinical disease.
AB - There is minimal published longitudinal data about pathogenic microorganisms in adults with bronchiectasis. Therefore a study was undertaken to assess the microbiologic profile over time in bronchiectasis. A prospective study of clinical and microbiologic outcomes was performed. Subjects were assessed by a respiratory physician and sputum sample were collected for analysis. Subjects were followed up and had repeat assessment performed. Eighty-nine subjects were followed up for a period of 5.7+/-3.6 years. On initial assessment the two most common pathogens isolated were Haemophilus influenzae (47 ) and Pseudomonas aeruginosa (12 ) whilst 21 had no pathogens isolated. On follow-up review results were similar (40 H. influenzae, 18 P. aeruginosa and 26 no pathogens). The prevalence of antibiotic resistance of isolates increased from 13 to 30 . Analysis of a series of H. influenzae isolates showed they were nearly all nontypeable and all were different subtypes. Subjects with no pathogens isolated from their sputum had the mildest disease, while subjects with P. aeruginosa had the most severe bronchiectasis. Many subjects with bronchiectasis are colonized with the same bacterium over an average follow-up of 5 years. Different pathogens are associated with different patterns of clinical disease.
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WWS-4NM5S4Y-1&_user=542840&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000027659&_vera
M3 - Article
VL - 101
SP - 1633
EP - 1638
JO - Respiratory Medicine
JF - Respiratory Medicine
SN - 0954-6111
IS - 8
ER -