Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases

Laurence Macia, Alison N Thorburn, Lauren C Binge, Eliana Marino Moreno, Kate E Rogers, Kendle M Maslowski, Angelica T Vieira, Jan Kranich, Charles R Mackay

    Research output: Contribution to journalArticleResearchpeer-review

    112 Citations (Scopus)

    Abstract

    Certain autoimmune diseases as well as asthma have increased in recent decades, particularly in developed countries. The hygiene hypothesis has been the prevailing model to account for this increase; however, epidemiology studies also support the contribution of diet and obesity to inflammatory diseases. Diet affects the composition of the gut microbiota, and recent studies have identified various molecules and mechanisms that connect diet, the gut microbiota, and immune responses. Herein, we discuss the effects of microbial metabolites, such as short chain fatty acids, on epithelial integrity as well as immune cell function. We propose that dysbiosis contributes to compromised epithelial integrity and disrupted immune tolerance. In addition, dietary molecules affect the function of immune cells directly, particularly through lipid G-protein coupled receptors such as GPR43.
    Original languageEnglish
    Pages (from-to)164 - 176
    Number of pages13
    JournalImmunological Reviews
    Volume245
    Issue number1
    DOIs
    Publication statusPublished - 2012

    Cite this

    Macia, Laurence ; Thorburn, Alison N ; Binge, Lauren C ; Marino Moreno, Eliana ; Rogers, Kate E ; Maslowski, Kendle M ; Vieira, Angelica T ; Kranich, Jan ; Mackay, Charles R. / Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases. In: Immunological Reviews. 2012 ; Vol. 245, No. 1. pp. 164 - 176.
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    abstract = "Certain autoimmune diseases as well as asthma have increased in recent decades, particularly in developed countries. The hygiene hypothesis has been the prevailing model to account for this increase; however, epidemiology studies also support the contribution of diet and obesity to inflammatory diseases. Diet affects the composition of the gut microbiota, and recent studies have identified various molecules and mechanisms that connect diet, the gut microbiota, and immune responses. Herein, we discuss the effects of microbial metabolites, such as short chain fatty acids, on epithelial integrity as well as immune cell function. We propose that dysbiosis contributes to compromised epithelial integrity and disrupted immune tolerance. In addition, dietary molecules affect the function of immune cells directly, particularly through lipid G-protein coupled receptors such as GPR43.",
    author = "Laurence Macia and Thorburn, {Alison N} and Binge, {Lauren C} and {Marino Moreno}, Eliana and Rogers, {Kate E} and Maslowski, {Kendle M} and Vieira, {Angelica T} and Jan Kranich and Mackay, {Charles R}",
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    Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases. / Macia, Laurence; Thorburn, Alison N; Binge, Lauren C; Marino Moreno, Eliana; Rogers, Kate E; Maslowski, Kendle M; Vieira, Angelica T; Kranich, Jan; Mackay, Charles R.

    In: Immunological Reviews, Vol. 245, No. 1, 2012, p. 164 - 176.

    Research output: Contribution to journalArticleResearchpeer-review

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    AU - Macia, Laurence

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    AU - Binge, Lauren C

    AU - Marino Moreno, Eliana

    AU - Rogers, Kate E

    AU - Maslowski, Kendle M

    AU - Vieira, Angelica T

    AU - Kranich, Jan

    AU - Mackay, Charles R

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    AB - Certain autoimmune diseases as well as asthma have increased in recent decades, particularly in developed countries. The hygiene hypothesis has been the prevailing model to account for this increase; however, epidemiology studies also support the contribution of diet and obesity to inflammatory diseases. Diet affects the composition of the gut microbiota, and recent studies have identified various molecules and mechanisms that connect diet, the gut microbiota, and immune responses. Herein, we discuss the effects of microbial metabolites, such as short chain fatty acids, on epithelial integrity as well as immune cell function. We propose that dysbiosis contributes to compromised epithelial integrity and disrupted immune tolerance. In addition, dietary molecules affect the function of immune cells directly, particularly through lipid G-protein coupled receptors such as GPR43.

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