TY - JOUR
T1 - Microbial Genomics
T2 - Innovative Targets and Mechanisms
AU - Alkatheri, Asma Hussain
AU - Yap, Polly Soo Xi
AU - Abushelaibi, Aisha
AU - Lai, Kok Song
AU - Cheng, Wan Hee
AU - Erin Lim, Swee Hua
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/2
Y1 - 2023/2
N2 - Multidrug resistance (MDR) has become an increasing threat to global health because bacteria can develop resistance to antibiotics over time. Scientists worldwide are searching for new approaches that go beyond traditional antibiotic discovery and development pipelines. Advances in genomics, however, opened up an unexplored therapeutic opportunity for the discovery of new antibacterial agents. Genomic approaches have been used to discover several novel antibiotics that target critical processes for bacterial growth and survival, including histidine kinases (HKs), LpxC, FabI, peptide deformylase (PDF), and aminoacyl-tRNA synthetases (AaRS). In this review, we will discuss the use of microbial genomics in the search for innovative and promising drug targets as well as the mechanisms of action for novel antimicrobial agents. We will also discuss future directions on how the utilization of the microbial genomics approach could improve the odds of antibiotic development having a more successful outcome.
AB - Multidrug resistance (MDR) has become an increasing threat to global health because bacteria can develop resistance to antibiotics over time. Scientists worldwide are searching for new approaches that go beyond traditional antibiotic discovery and development pipelines. Advances in genomics, however, opened up an unexplored therapeutic opportunity for the discovery of new antibacterial agents. Genomic approaches have been used to discover several novel antibiotics that target critical processes for bacterial growth and survival, including histidine kinases (HKs), LpxC, FabI, peptide deformylase (PDF), and aminoacyl-tRNA synthetases (AaRS). In this review, we will discuss the use of microbial genomics in the search for innovative and promising drug targets as well as the mechanisms of action for novel antimicrobial agents. We will also discuss future directions on how the utilization of the microbial genomics approach could improve the odds of antibiotic development having a more successful outcome.
KW - antibiotic resistance
KW - biosynthetic gene clusters
KW - genomics
KW - novel antibiotics
KW - virulence factors
KW - whole genome sequence
UR - http://www.scopus.com/inward/record.url?scp=85148851025&partnerID=8YFLogxK
U2 - 10.3390/antibiotics12020190
DO - 10.3390/antibiotics12020190
M3 - Review Article
C2 - 36830101
AN - SCOPUS:85148851025
SN - 2079-6382
VL - 12
JO - Antibiotics
JF - Antibiotics
IS - 2
M1 - 190
ER -