Microbial Genomics: Innovative Targets and Mechanisms

Asma Hussain Alkatheri, Polly Soo Xi Yap, Aisha Abushelaibi, Kok Song Lai, Wan Hee Cheng, Swee Hua Erin Lim

Research output: Contribution to journalReview ArticleResearchpeer-review


Multidrug resistance (MDR) has become an increasing threat to global health because bacteria can develop resistance to antibiotics over time. Scientists worldwide are searching for new approaches that go beyond traditional antibiotic discovery and development pipelines. Advances in genomics, however, opened up an unexplored therapeutic opportunity for the discovery of new antibacterial agents. Genomic approaches have been used to discover several novel antibiotics that target critical processes for bacterial growth and survival, including histidine kinases (HKs), LpxC, FabI, peptide deformylase (PDF), and aminoacyl-tRNA synthetases (AaRS). In this review, we will discuss the use of microbial genomics in the search for innovative and promising drug targets as well as the mechanisms of action for novel antimicrobial agents. We will also discuss future directions on how the utilization of the microbial genomics approach could improve the odds of antibiotic development having a more successful outcome.

Original languageEnglish
Article number190
Number of pages24
Issue number2
Publication statusPublished - Feb 2023


  • antibiotic resistance
  • biosynthetic gene clusters
  • genomics
  • novel antibiotics
  • virulence factors
  • whole genome sequence

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