Microbes as architects of colonic patterning

Dena Lyras; Wing Hei Chan; Helen E. Abud

doi:10.1016/j.chom.2026.03.010

Microbes as architects of colonic patterning

Research output: Contribution to journal › Comment / Debate › Other › peer-review

Abstract

The colonic epithelium is organized in functional regions and interacts with an abundant microbial community. In Cell , Rispal et al. discover that regionalization depends on microbes, with proximal identity regulated by microbial nicotinic acid-induced PPARα activation in the epithelium. Changes in tissue identity reshape zones of tissue injury.

Original language	English
Pages (from-to)	545-547
Number of pages	3
Journal	Cell Host and Microbe
Volume	34
Issue number	4
DOIs	https://doi.org/10.1016/j.chom.2026.03.010
Publication status	Published - 8 Apr 2026

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title = "Microbes as architects of colonic patterning",

abstract = "The colonic epithelium is organized in functional regions and interacts with an abundant microbial community. In Cell , Rispal et al. discover that regionalization depends on microbes, with proximal identity regulated by microbial nicotinic acid-induced PPARα activation in the epithelium. Changes in tissue identity reshape zones of tissue injury.",

author = "Dena Lyras and Chan, \{Wing Hei\} and Abud, \{Helen E.\}",

note = "Publisher Copyright: {\textcopyright} 2026 Elsevier Inc.",

year = "2026",

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doi = "10.1016/j.chom.2026.03.010",

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T1 - Microbes as architects of colonic patterning

AU - Lyras, Dena

AU - Chan, Wing Hei

A2 - Abud, Helen E.

PY - 2026/4/8

Y1 - 2026/4/8

N2 - The colonic epithelium is organized in functional regions and interacts with an abundant microbial community. In Cell , Rispal et al. discover that regionalization depends on microbes, with proximal identity regulated by microbial nicotinic acid-induced PPARα activation in the epithelium. Changes in tissue identity reshape zones of tissue injury.

AB - The colonic epithelium is organized in functional regions and interacts with an abundant microbial community. In Cell , Rispal et al. discover that regionalization depends on microbes, with proximal identity regulated by microbial nicotinic acid-induced PPARα activation in the epithelium. Changes in tissue identity reshape zones of tissue injury.

UR - https://www.scopus.com/pages/publications/105034985785

U2 - 10.1016/j.chom.2026.03.010

DO - 10.1016/j.chom.2026.03.010

M3 - Comment / Debate

C2 - 41956060

AN - SCOPUS:105034985785

SN - 1931-3128

VL - 34

SP - 545

EP - 547

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 4

ER -

Microbes as architects of colonic patterning

Abstract

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