Microalbuminuria: Prognostic and Therapeutic Implications in Diabetes Mellitus

R. E. Gilbert; M. E. Cooper; P. G. McNally; R. C. O'Brien; J. Taft; G. Jerums

doi:10.1111/j.1464-5491.1994.tb00325.x

Microalbuminuria: Prognostic and Therapeutic Implications in Diabetes Mellitus

R. E. Gilbert, M. E. Cooper, P. G. McNally, R. C. O'Brien, J. Taft, G. Jerums

Research output: Contribution to journal › Review Article › Research › peer-review

59 Citations (Scopus)

Abstract

Thirty years following the development of the first radioimmunoassay for albumin, microalbuminuria is widely acknowledged as an important predictor of overt nephropathy in patients with Type 1 diabetes and of cardiovascular mortality in Type 2 diabetes. In addition, there is accumulating evidence to suggest that diabetic patients with microalbuminuria may have more advanced retinopathy, higher blood pressure, and worse dyslipidaemia than patients with normal albumin excretion rates. Recent studies have focused on the role of intervention, principally with antihypertensive therapy and intensive glycaemic control, in reducing microalbuminuria. While successful in reducing urinary albumin excretion it remains to be established whether such therapies will be translated into a reduction in renal failure and decreased cardiovascular mobidity and mortality. 1994 Diabetes UK

Original language	English
Pages (from-to)	636-645
Number of pages	10
Journal	Diabetic Medicine
Volume	11
Issue number	7
DOIs	https://doi.org/10.1111/j.1464-5491.1994.tb00325.x
Publication status	Published - 1 Jan 1994
Externally published	Yes

Keywords

Antihypertensive therapy
Cardiovascular disease
Microalbuminuria
Nephropathy
Type 1 diabetes
Type 2 diabetes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.1464-5491.1994.tb00325.x

Cite this

@article{81cc3838b42e4a25987ffeff9e7d43d3,

title = "Microalbuminuria: Prognostic and Therapeutic Implications in Diabetes Mellitus",

abstract = "Thirty years following the development of the first radioimmunoassay for albumin, microalbuminuria is widely acknowledged as an important predictor of overt nephropathy in patients with Type 1 diabetes and of cardiovascular mortality in Type 2 diabetes. In addition, there is accumulating evidence to suggest that diabetic patients with microalbuminuria may have more advanced retinopathy, higher blood pressure, and worse dyslipidaemia than patients with normal albumin excretion rates. Recent studies have focused on the role of intervention, principally with antihypertensive therapy and intensive glycaemic control, in reducing microalbuminuria. While successful in reducing urinary albumin excretion it remains to be established whether such therapies will be translated into a reduction in renal failure and decreased cardiovascular mobidity and mortality. 1994 Diabetes UK",

keywords = "Antihypertensive therapy, Cardiovascular disease, Microalbuminuria, Nephropathy, Type 1 diabetes, Type 2 diabetes",

author = "Gilbert, {R. E.} and Cooper, {M. E.} and McNally, {P. G.} and O'Brien, {R. C.} and J. Taft and G. Jerums",

year = "1994",

month = jan,

day = "1",

doi = "10.1111/j.1464-5491.1994.tb00325.x",

language = "English",

volume = "11",

pages = "636--645",

journal = "Diabetic Medicine",

issn = "0742-3071",

publisher = "Wiley-Blackwell",

number = "7",

}

TY - JOUR

T1 - Microalbuminuria

T2 - Prognostic and Therapeutic Implications in Diabetes Mellitus

AU - Gilbert, R. E.

AU - Cooper, M. E.

AU - McNally, P. G.

AU - O'Brien, R. C.

AU - Taft, J.

AU - Jerums, G.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - Thirty years following the development of the first radioimmunoassay for albumin, microalbuminuria is widely acknowledged as an important predictor of overt nephropathy in patients with Type 1 diabetes and of cardiovascular mortality in Type 2 diabetes. In addition, there is accumulating evidence to suggest that diabetic patients with microalbuminuria may have more advanced retinopathy, higher blood pressure, and worse dyslipidaemia than patients with normal albumin excretion rates. Recent studies have focused on the role of intervention, principally with antihypertensive therapy and intensive glycaemic control, in reducing microalbuminuria. While successful in reducing urinary albumin excretion it remains to be established whether such therapies will be translated into a reduction in renal failure and decreased cardiovascular mobidity and mortality. 1994 Diabetes UK

AB - Thirty years following the development of the first radioimmunoassay for albumin, microalbuminuria is widely acknowledged as an important predictor of overt nephropathy in patients with Type 1 diabetes and of cardiovascular mortality in Type 2 diabetes. In addition, there is accumulating evidence to suggest that diabetic patients with microalbuminuria may have more advanced retinopathy, higher blood pressure, and worse dyslipidaemia than patients with normal albumin excretion rates. Recent studies have focused on the role of intervention, principally with antihypertensive therapy and intensive glycaemic control, in reducing microalbuminuria. While successful in reducing urinary albumin excretion it remains to be established whether such therapies will be translated into a reduction in renal failure and decreased cardiovascular mobidity and mortality. 1994 Diabetes UK

KW - Antihypertensive therapy

KW - Cardiovascular disease

KW - Microalbuminuria

KW - Nephropathy

KW - Type 1 diabetes

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=0028049752&partnerID=8YFLogxK

U2 - 10.1111/j.1464-5491.1994.tb00325.x

DO - 10.1111/j.1464-5491.1994.tb00325.x

M3 - Review Article

C2 - 7955987

AN - SCOPUS:0028049752

SN - 0742-3071

VL - 11

SP - 636

EP - 645

JO - Diabetic Medicine

JF - Diabetic Medicine

IS - 7

ER -

Microalbuminuria: Prognostic and Therapeutic Implications in Diabetes Mellitus

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Cite this