Microalbuminuria: Prognostic and Therapeutic Implications in Diabetes Mellitus

R. E. Gilbert, M. E. Cooper, P. G. McNally, R. C. O'Brien, J. Taft, G. Jerums

Research output: Contribution to journalReview ArticleResearchpeer-review

59 Citations (Scopus)


Thirty years following the development of the first radioimmunoassay for albumin, microalbuminuria is widely acknowledged as an important predictor of overt nephropathy in patients with Type 1 diabetes and of cardiovascular mortality in Type 2 diabetes. In addition, there is accumulating evidence to suggest that diabetic patients with microalbuminuria may have more advanced retinopathy, higher blood pressure, and worse dyslipidaemia than patients with normal albumin excretion rates. Recent studies have focused on the role of intervention, principally with antihypertensive therapy and intensive glycaemic control, in reducing microalbuminuria. While successful in reducing urinary albumin excretion it remains to be established whether such therapies will be translated into a reduction in renal failure and decreased cardiovascular mobidity and mortality. 1994 Diabetes UK

Original languageEnglish
Pages (from-to)636-645
Number of pages10
JournalDiabetic Medicine
Issue number7
Publication statusPublished - 1 Jan 1994
Externally publishedYes


  • Antihypertensive therapy
  • Cardiovascular disease
  • Microalbuminuria
  • Nephropathy
  • Type 1 diabetes
  • Type 2 diabetes

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