Micelle-based brain-targeted drug delivery enabled by a nicotine acetylcholine receptor ligand

Changyou Zhan; Bian Li; Luojuan Hu; Xiaoli Wei; Linyin Feng; Wei Fu; Weiyue Lu

doi:10.1002/anie.201100875

Micelle-based brain-targeted drug delivery enabled by a nicotine acetylcholine receptor ligand

Changyou Zhan, Bian Li, Luojuan Hu, Xiaoli Wei, Linyin Feng, Wei Fu, Weiyue Lu

Research output: Contribution to journal › Article › Research › peer-review

138 Citations (Scopus)

Abstract

Candid candoxin: A 16-residue peptide (CDX) that is derived from candoxin binds with a high affinity to nicotinic acetylcholine receptors (see picture), which are highly expressed on the blood-brain barrier. Invivo biodistribution and the anti-glioblastoma effect indicate the potential of CDX as a ligand to enable brain-targeted drug delivery.

Original language	English
Pages (from-to)	5482-5485
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	24
DOIs	https://doi.org/10.1002/anie.201100875
Publication status	Published - 6 Jun 2011
Externally published	Yes

Keywords

drug delivery
micelles
nanomedicine
peptides
receptors

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10.1002/anie.201100875

Cite this

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AU - Wei, Xiaoli

AU - Feng, Linyin

AU - Fu, Wei

AU - Lu, Weiyue

PY - 2011/6/6

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KW - micelles

KW - nanomedicine

KW - peptides

KW - receptors

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Micelle-based brain-targeted drug delivery enabled by a nicotine acetylcholine receptor ligand

Abstract

Keywords

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