Micelle-based brain-targeted drug delivery enabled by a nicotine acetylcholine receptor ligand

Changyou Zhan, Bian Li, Luojuan Hu, Xiaoli Wei, Linyin Feng, Da-Wei Fu, Weiyue Lu

Research output: Contribution to journalArticleResearchpeer-review

80 Citations (Scopus)

Abstract

Candid candoxin: A 16-residue peptide (CDX) that is derived from candoxin binds with a high affinity to nicotinic acetylcholine receptors (see picture), which are highly expressed on the blood-brain barrier. Invivo biodistribution and the anti-glioblastoma effect indicate the potential of CDX as a ligand to enable brain-targeted drug delivery.

Original languageEnglish
Pages (from-to)5482-5485
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number24
DOIs
Publication statusPublished - 6 Jun 2011
Externally publishedYes

Keywords

  • drug delivery
  • micelles
  • nanomedicine
  • peptides
  • receptors

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