TY - JOUR
T1 - Mice with a null mutation of the TGFα gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation
AU - Mann, G. Bruce
AU - Fowler, Kerry J.
AU - Gabriel, Anastasia
AU - Nice, Edouard C.
AU - Williams, R. Lindsay
AU - Dunn, Ashley R.
PY - 1993/4/23
Y1 - 1993/4/23
N2 - Mice homozygous for a disrupted transforming growth factor α (TGFα) gene are healthy and fertile, although some older mice show evidence of corneal inflammation. In contrast with TGFα +/- and +/+ animals, TGFα -/- mice have a pronounced waviness of the coat. Histological examination of the skin from TGFα -/- mice reveals a dramatic derangement of hair follicles. Mice with a disrupted TGFα gene also have curly whiskers, first evident on the day of birth. The phenotype of TGFα -/- mice is remarkably similar to that of the mouse mutant waved-1 (wa-1). Offspring resulting from crosses between TGFα -/- and wa-1 mice display the curly whisker-coat phenotype, indicating that the basis of the wa-1 phenotype is a mutation in the TGFα gene. These observations suggest that TGFα plays a pivotal role in determining skin architecture and in regulating hair development.
AB - Mice homozygous for a disrupted transforming growth factor α (TGFα) gene are healthy and fertile, although some older mice show evidence of corneal inflammation. In contrast with TGFα +/- and +/+ animals, TGFα -/- mice have a pronounced waviness of the coat. Histological examination of the skin from TGFα -/- mice reveals a dramatic derangement of hair follicles. Mice with a disrupted TGFα gene also have curly whiskers, first evident on the day of birth. The phenotype of TGFα -/- mice is remarkably similar to that of the mouse mutant waved-1 (wa-1). Offspring resulting from crosses between TGFα -/- and wa-1 mice display the curly whisker-coat phenotype, indicating that the basis of the wa-1 phenotype is a mutation in the TGFα gene. These observations suggest that TGFα plays a pivotal role in determining skin architecture and in regulating hair development.
UR - http://www.scopus.com/inward/record.url?scp=0027315183&partnerID=8YFLogxK
U2 - 10.1016/0092-8674(93)90227-H
DO - 10.1016/0092-8674(93)90227-H
M3 - Article
C2 - 8477444
AN - SCOPUS:0027315183
VL - 73
SP - 249
EP - 261
JO - Cell
JF - Cell
SN - 0092-8674
IS - 2
ER -