Mice with a null mutation of the TGFα gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation

G. Bruce Mann, Kerry J. Fowler, Anastasia Gabriel, Edouard C. Nice, R. Lindsay Williams, Ashley R. Dunn

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Abstract

Mice homozygous for a disrupted transforming growth factor α (TGFα) gene are healthy and fertile, although some older mice show evidence of corneal inflammation. In contrast with TGFα +/- and +/+ animals, TGFα -/- mice have a pronounced waviness of the coat. Histological examination of the skin from TGFα -/- mice reveals a dramatic derangement of hair follicles. Mice with a disrupted TGFα gene also have curly whiskers, first evident on the day of birth. The phenotype of TGFα -/- mice is remarkably similar to that of the mouse mutant waved-1 (wa-1). Offspring resulting from crosses between TGFα -/- and wa-1 mice display the curly whisker-coat phenotype, indicating that the basis of the wa-1 phenotype is a mutation in the TGFα gene. These observations suggest that TGFα plays a pivotal role in determining skin architecture and in regulating hair development.

Original languageEnglish
Pages (from-to)249-261
Number of pages13
JournalCell
Volume73
Issue number2
DOIs
Publication statusPublished - 23 Apr 1993
Externally publishedYes

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