Mice lacking the transcription factor subunit Rel can clear an influenza infection and have functional anti-viral cytotoxic T cells but do not develop an optimal antibody response

Leanne Harling-McNabb, Georgia Deliyannis, David C Jackson, Steven Demetrious Gerondakis, George Grigoriadis, Lorena Elizabeth Brown

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Rel, a haemopoietic cell-restricted member of the NF-I?B/Rel family of transcription factors, has recently been shown to be important in the function of B and T lymphocytes. In an attempt to understand the role of this protein in the immune response, we examined the ability of Rel(-/-) mice to counter an influenza virus infection. Normal levels of virus-specific cytotoxic T cells induced in Rel(-/-) mice were able to clear virus from the lungs, albeit with somewhat delayed kinetics compared to normal mice. Rel(-/-) mice did, however, display a markedly reduced T cell proliferative response to the virus, and exhibited impaired local and systemic influenza virus-specific antibody responses. This defect was sufficient to result in an inability of vaccinated mice, but not of previously infected mice, to acquire antibody-dependent protective immunity to reinfection with the same virus. These findings establish that during the response to influenza virus, Rel function allows optimal development of humoral immunity, a role that apparently cannot be fulfilled by other NF-I?B/Rel proteins.
Original languageEnglish
Pages (from-to)1431 - 1439
Number of pages9
JournalInternational Immunology
Volume11
Issue number9
DOIs
Publication statusPublished - 1999

Cite this

@article{8dac8bdf0393409b9e9eee8600521613,
title = "Mice lacking the transcription factor subunit Rel can clear an influenza infection and have functional anti-viral cytotoxic T cells but do not develop an optimal antibody response",
abstract = "Rel, a haemopoietic cell-restricted member of the NF-I?B/Rel family of transcription factors, has recently been shown to be important in the function of B and T lymphocytes. In an attempt to understand the role of this protein in the immune response, we examined the ability of Rel(-/-) mice to counter an influenza virus infection. Normal levels of virus-specific cytotoxic T cells induced in Rel(-/-) mice were able to clear virus from the lungs, albeit with somewhat delayed kinetics compared to normal mice. Rel(-/-) mice did, however, display a markedly reduced T cell proliferative response to the virus, and exhibited impaired local and systemic influenza virus-specific antibody responses. This defect was sufficient to result in an inability of vaccinated mice, but not of previously infected mice, to acquire antibody-dependent protective immunity to reinfection with the same virus. These findings establish that during the response to influenza virus, Rel function allows optimal development of humoral immunity, a role that apparently cannot be fulfilled by other NF-I?B/Rel proteins.",
author = "Leanne Harling-McNabb and Georgia Deliyannis and Jackson, {David C} and Gerondakis, {Steven Demetrious} and George Grigoriadis and Brown, {Lorena Elizabeth}",
year = "1999",
doi = "10.1093/intimm/11.9.1431",
language = "English",
volume = "11",
pages = "1431 -- 1439",
journal = "International Immunology",
issn = "0953-8178",
publisher = "Oxford University Press",
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}

Mice lacking the transcription factor subunit Rel can clear an influenza infection and have functional anti-viral cytotoxic T cells but do not develop an optimal antibody response. / Harling-McNabb, Leanne; Deliyannis, Georgia; Jackson, David C; Gerondakis, Steven Demetrious; Grigoriadis, George; Brown, Lorena Elizabeth.

In: International Immunology, Vol. 11, No. 9, 1999, p. 1431 - 1439.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Mice lacking the transcription factor subunit Rel can clear an influenza infection and have functional anti-viral cytotoxic T cells but do not develop an optimal antibody response

AU - Harling-McNabb, Leanne

AU - Deliyannis, Georgia

AU - Jackson, David C

AU - Gerondakis, Steven Demetrious

AU - Grigoriadis, George

AU - Brown, Lorena Elizabeth

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AB - Rel, a haemopoietic cell-restricted member of the NF-I?B/Rel family of transcription factors, has recently been shown to be important in the function of B and T lymphocytes. In an attempt to understand the role of this protein in the immune response, we examined the ability of Rel(-/-) mice to counter an influenza virus infection. Normal levels of virus-specific cytotoxic T cells induced in Rel(-/-) mice were able to clear virus from the lungs, albeit with somewhat delayed kinetics compared to normal mice. Rel(-/-) mice did, however, display a markedly reduced T cell proliferative response to the virus, and exhibited impaired local and systemic influenza virus-specific antibody responses. This defect was sufficient to result in an inability of vaccinated mice, but not of previously infected mice, to acquire antibody-dependent protective immunity to reinfection with the same virus. These findings establish that during the response to influenza virus, Rel function allows optimal development of humoral immunity, a role that apparently cannot be fulfilled by other NF-I?B/Rel proteins.

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