MHC and MHC-like molecules

Structural perspectives on the design of the molecular vaccines

Vasso Apostolopoulos, Elizabeth Yuriev, Eliada Lazoura, Minmin Yu, Paul A. Ramsland

Research output: Contribution to journalReview ArticleResearchpeer-review

7 Citations (Scopus)

Abstract

Major histocompatibility complex (MHC) molecules bind and present short antigenic peptide fragments on the surface of antigen presenting cells (APCs) to T cell receptors. Recognition of peptide-MHC complexes by T cells initiates a cascade of signals in T cells and activated cells either destroy or help to destroy the APC. The MHCs are divided into three subgroups: MHC class I, MHC class II and MHC class III. In addition, non-classical MHC molecules and MHC-like molecules play a pivotal role in shaping our understanding of the immune response. In the design of molecular vaccines for the treatment of diseases, an understanding of the three-dimensional structure of MHC, its interaction with peptide ligands, and its interaction with the T cell receptor are important prerequisites, all of which are discussed herein.

Original languageEnglish
Pages (from-to)400-409
Number of pages10
JournalHuman Vaccines
Volume4
Issue number6
DOIs
Publication statusPublished - 1 Jan 2008

Keywords

  • Classical MHC
  • Crystallography
  • H-2M
  • H-2Q
  • H-2T
  • HFE
  • HLA-DM
  • HLA-DO
  • HLA-E
  • HLA-F
  • HLA-G
  • MHC class I
  • MHC class II
  • MHC class III
  • Non-Canonical peptides
  • Non-classical MHC
  • Peptide
  • TCR

Cite this

@article{ece1b697fca04708822ea1c4c60f130c,
title = "MHC and MHC-like molecules: Structural perspectives on the design of the molecular vaccines",
abstract = "Major histocompatibility complex (MHC) molecules bind and present short antigenic peptide fragments on the surface of antigen presenting cells (APCs) to T cell receptors. Recognition of peptide-MHC complexes by T cells initiates a cascade of signals in T cells and activated cells either destroy or help to destroy the APC. The MHCs are divided into three subgroups: MHC class I, MHC class II and MHC class III. In addition, non-classical MHC molecules and MHC-like molecules play a pivotal role in shaping our understanding of the immune response. In the design of molecular vaccines for the treatment of diseases, an understanding of the three-dimensional structure of MHC, its interaction with peptide ligands, and its interaction with the T cell receptor are important prerequisites, all of which are discussed herein.",
keywords = "Classical MHC, Crystallography, H-2M, H-2Q, H-2T, HFE, HLA-DM, HLA-DO, HLA-E, HLA-F, HLA-G, MHC class I, MHC class II, MHC class III, Non-Canonical peptides, Non-classical MHC, Peptide, TCR",
author = "Vasso Apostolopoulos and Elizabeth Yuriev and Eliada Lazoura and Minmin Yu and Ramsland, {Paul A.}",
year = "2008",
month = "1",
day = "1",
doi = "10.4161/hv.4.6.6690",
language = "English",
volume = "4",
pages = "400--409",
journal = "Human Vaccines & Immunotherapeutics",
issn = "2164-5515",
publisher = "Taylor & Francis",
number = "6",

}

MHC and MHC-like molecules : Structural perspectives on the design of the molecular vaccines. / Apostolopoulos, Vasso; Yuriev, Elizabeth; Lazoura, Eliada; Yu, Minmin; Ramsland, Paul A.

In: Human Vaccines, Vol. 4, No. 6, 01.01.2008, p. 400-409.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - MHC and MHC-like molecules

T2 - Structural perspectives on the design of the molecular vaccines

AU - Apostolopoulos, Vasso

AU - Yuriev, Elizabeth

AU - Lazoura, Eliada

AU - Yu, Minmin

AU - Ramsland, Paul A.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Major histocompatibility complex (MHC) molecules bind and present short antigenic peptide fragments on the surface of antigen presenting cells (APCs) to T cell receptors. Recognition of peptide-MHC complexes by T cells initiates a cascade of signals in T cells and activated cells either destroy or help to destroy the APC. The MHCs are divided into three subgroups: MHC class I, MHC class II and MHC class III. In addition, non-classical MHC molecules and MHC-like molecules play a pivotal role in shaping our understanding of the immune response. In the design of molecular vaccines for the treatment of diseases, an understanding of the three-dimensional structure of MHC, its interaction with peptide ligands, and its interaction with the T cell receptor are important prerequisites, all of which are discussed herein.

AB - Major histocompatibility complex (MHC) molecules bind and present short antigenic peptide fragments on the surface of antigen presenting cells (APCs) to T cell receptors. Recognition of peptide-MHC complexes by T cells initiates a cascade of signals in T cells and activated cells either destroy or help to destroy the APC. The MHCs are divided into three subgroups: MHC class I, MHC class II and MHC class III. In addition, non-classical MHC molecules and MHC-like molecules play a pivotal role in shaping our understanding of the immune response. In the design of molecular vaccines for the treatment of diseases, an understanding of the three-dimensional structure of MHC, its interaction with peptide ligands, and its interaction with the T cell receptor are important prerequisites, all of which are discussed herein.

KW - Classical MHC

KW - Crystallography

KW - H-2M

KW - H-2Q

KW - H-2T

KW - HFE

KW - HLA-DM

KW - HLA-DO

KW - HLA-E

KW - HLA-F

KW - HLA-G

KW - MHC class I

KW - MHC class II

KW - MHC class III

KW - Non-Canonical peptides

KW - Non-classical MHC

KW - Peptide

KW - TCR

UR - http://www.scopus.com/inward/record.url?scp=56149113270&partnerID=8YFLogxK

U2 - 10.4161/hv.4.6.6690

DO - 10.4161/hv.4.6.6690

M3 - Review Article

VL - 4

SP - 400

EP - 409

JO - Human Vaccines & Immunotherapeutics

JF - Human Vaccines & Immunotherapeutics

SN - 2164-5515

IS - 6

ER -