MHC and MHC-like molecules: Structural perspectives on the design of the molecular vaccines

Vasso Apostolopoulos, Elizabeth Yuriev, Eliada Lazoura, Minmin Yu, Paul A. Ramsland

Research output: Contribution to journalReview ArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Major histocompatibility complex (MHC) molecules bind and present short antigenic peptide fragments on the surface of antigen presenting cells (APCs) to T cell receptors. Recognition of peptide-MHC complexes by T cells initiates a cascade of signals in T cells and activated cells either destroy or help to destroy the APC. The MHCs are divided into three subgroups: MHC class I, MHC class II and MHC class III. In addition, non-classical MHC molecules and MHC-like molecules play a pivotal role in shaping our understanding of the immune response. In the design of molecular vaccines for the treatment of diseases, an understanding of the three-dimensional structure of MHC, its interaction with peptide ligands, and its interaction with the T cell receptor are important prerequisites, all of which are discussed herein.

Original languageEnglish
Pages (from-to)400-409
Number of pages10
JournalHuman Vaccines
Volume4
Issue number6
DOIs
Publication statusPublished - 1 Jan 2008

Keywords

  • Classical MHC
  • Crystallography
  • H-2M
  • H-2Q
  • H-2T
  • HFE
  • HLA-DM
  • HLA-DO
  • HLA-E
  • HLA-F
  • HLA-G
  • MHC class I
  • MHC class II
  • MHC class III
  • Non-Canonical peptides
  • Non-classical MHC
  • Peptide
  • TCR

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