TY - JOUR
T1 - Methylphenidate side effect profile is influenced by genetic variation in the attention-deficit/hyperactivity disorder-associated CES1 gene
AU - Johnson, Katherine A
AU - Barry, Edwina
AU - Lambert, David
AU - Fitzgerald, Michael F
AU - McNicholas, Fiona
AU - Kirley, Aiveen
AU - Gill, Michael
AU - Bellgrove, Mark Andrew
AU - Hawi, Ziarih
PY - 2013
Y1 - 2013
N2 - A naturalistic, prospective study of the influence of genetic variation on dose prescribed, clinical response, and side effects related to stimulant medication in 77 children with attention-deficit/hyperactivity disorder (ADHD) was undertaken. The influence of genetic variation of the CES1 gene coding for carboxylesterase 1A1 (CES1A1), the major enzyme responsible for the first-pass, stereoselective metabolism of methylphenidate, was investigated.
AB - A naturalistic, prospective study of the influence of genetic variation on dose prescribed, clinical response, and side effects related to stimulant medication in 77 children with attention-deficit/hyperactivity disorder (ADHD) was undertaken. The influence of genetic variation of the CES1 gene coding for carboxylesterase 1A1 (CES1A1), the major enzyme responsible for the first-pass, stereoselective metabolism of methylphenidate, was investigated.
UR - http://online.liebertpub.com/doi/pdf/10.1089/cap.2013.0032
U2 - 10.1089/cap.2013.0032
DO - 10.1089/cap.2013.0032
M3 - Article
SN - 1044-5463
VL - 23
SP - 655
EP - 664
JO - Journal of Child and Adolescent Psychopharmacology
JF - Journal of Child and Adolescent Psychopharmacology
IS - 10
ER -