Methylphenidate side effect profile is influenced by genetic variation in the attention-deficit/hyperactivity disorder-associated CES1 gene

Katherine A Johnson, Edwina Barry, David Lambert, Michael F Fitzgerald, Fiona McNicholas, Aiveen Kirley, Michael Gill, Mark Andrew Bellgrove, Ziarih Hawi

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Abstract

A naturalistic, prospective study of the influence of genetic variation on dose prescribed, clinical response, and side effects related to stimulant medication in 77 children with attention-deficit/hyperactivity disorder (ADHD) was undertaken. The influence of genetic variation of the CES1 gene coding for carboxylesterase 1A1 (CES1A1), the major enzyme responsible for the first-pass, stereoselective metabolism of methylphenidate, was investigated.
Original languageEnglish
Pages (from-to)655 - 664
Number of pages10
JournalJournal of Child and Adolescent Psychopharmacology
Volume23
Issue number10
DOIs
Publication statusPublished - 2013

Cite this

Johnson, Katherine A ; Barry, Edwina ; Lambert, David ; Fitzgerald, Michael F ; McNicholas, Fiona ; Kirley, Aiveen ; Gill, Michael ; Bellgrove, Mark Andrew ; Hawi, Ziarih. / Methylphenidate side effect profile is influenced by genetic variation in the attention-deficit/hyperactivity disorder-associated CES1 gene. In: Journal of Child and Adolescent Psychopharmacology. 2013 ; Vol. 23, No. 10. pp. 655 - 664.
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Methylphenidate side effect profile is influenced by genetic variation in the attention-deficit/hyperactivity disorder-associated CES1 gene. / Johnson, Katherine A; Barry, Edwina; Lambert, David; Fitzgerald, Michael F; McNicholas, Fiona; Kirley, Aiveen; Gill, Michael; Bellgrove, Mark Andrew; Hawi, Ziarih.

In: Journal of Child and Adolescent Psychopharmacology, Vol. 23, No. 10, 2013, p. 655 - 664.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Bellgrove, Mark Andrew

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