Methods for understanding shear induced thrombus growth

Isaac Paul Pinar, Jane Arthur, Rob Andrews, Elizabeth Ellen Gardiner, Kris Ryan, Josie Joy Carberry

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Abstract

The formation of blood clots is a key process in preventing major blood loss. Novel techniques are presented that allow for both the quantitative and qualitative analysis of shear dependent thrombus formation in real-time. Techniques that allow for scanned real-time images to be time corrected and reconstructed into a three-dimensional (3D) surface are demonstrated. As past work has demonstrated platelet activation and the subsequent thrombus growth is highly shear sensitive (Nesbitt, 2009). In order to attain better understanding to the underlying mechanisms driving thrombus formation the novel techniques presented allow for the shear history of individual platelets to be correlated with factors such as overall thrombus growth. A combination of the methods presented provides a powerful tool towards analysing thrombus growth in a highly temporal and spatially accurate manner.

Original languageEnglish
Title of host publicationNinth International Symposium on Turbulence and Shear Flow Phenomena (TSFP-9)
EditorsStavros Tavoularis, Ivan Marusic
Place of PublicationMelbourne Vic Australia
PublisherUniversity of Melbourne
Pages1-5
Number of pages5
ISBN (Electronic)9780000000002
Publication statusPublished - 1 Jan 2015
EventTurbulence and Shear Flow Phenomena 2015 - The University of Melbourne, Melbourne, Australia
Duration: 30 Jun 20153 Jul 2015
Conference number: 9th
http://tsfp9.org/
http://www.tsfp-conference.org/proceedings/proceedings-of-tsfp-9-2015-melbourne.html

Publication series

Name9th International Symposium on Turbulence and Shear Flow Phenomena, TSFP 2015
Volume2

Conference

ConferenceTurbulence and Shear Flow Phenomena 2015
Abbreviated titleTSFP-9
CountryAustralia
CityMelbourne
Period30/06/153/07/15
Internet address

Cite this

Pinar, I. P., Arthur, J., Andrews, R., Gardiner, E. E., Ryan, K., & Carberry, J. J. (2015). Methods for understanding shear induced thrombus growth. In S. Tavoularis, & I. Marusic (Eds.), Ninth International Symposium on Turbulence and Shear Flow Phenomena (TSFP-9) (pp. 1-5). (9th International Symposium on Turbulence and Shear Flow Phenomena, TSFP 2015; Vol. 2). Melbourne Vic Australia: University of Melbourne.