TY - JOUR
T1 - Methodological decisions influence the identification of potential core outcomes in studies related to pre-eclampsia
T2 - an analysis informing the development of recommendations for future core outcome set developers
AU - Duffy, J.M.N.
AU - Hirsch, M.
AU - Ziebland, S.
AU - McManus, R.J.
AU - the International Collaboration to Harmonise Outcomes in Pre-eclampsia (iHOPE)
AU - Brown, Mark
AU - Gale, Chris
AU - Grobman, William
AU - Fitzpatrick, Ray
AU - Karumanchi, S. Ananth
AU - Lucas, Nuala
AU - Magee, Laura
AU - Mol, Ben
AU - Stark, Michael
AU - Thangaratinam, Shakila
AU - Wilson, Mathew
AU - van‘t Hooft, Janneke
AU - von Dadelszen, Peter
AU - Williamson, Paula R.
AU - Khan, Khalid S.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Objective: To quantify the effect of different methodological decisions on the identification of potential core outcomes to inform the development of recommendations for future core coutcome set developers. Design: Mixed methods study. Setting: A core outcome set for pre-eclampsia was used as an exemplar. Sample: A long list of potential core outcomes was developed by undertaking a systematic review of pre-eclampsia trials and performing a thematic analysis of in-depth patient interviews. Methods: Specific methods used to generate long lists of potential core outcomes were evaluated. Results: Different methodological decisions had a substantial impact on the identification of potential core outcomes. Extracting outcomes from published pre-eclampsia trials was an effective way of identifying 48 maternal, eight fetal, 25 neonatal outcomes, and eight patient-reported outcomes. Limiting the extraction of outcomes to primary outcomes or outcomes commonly reported in pre-eclampsia trials reduced the number and diversity of potential core outcomes identified. Thematic analysis of in-depth patient interviews ensured an additional five patient reported outcomes and six outcomes related to future child health were identified. Conclusions: Future core outcome set developers should use quantitative and qualitative methods when developing a long list of potential core outcomes. Tweetable abstract: @OfficialNIHR research published in @BJOGtweets informs new recommendations for future @coreoutcomes developers.
AB - Objective: To quantify the effect of different methodological decisions on the identification of potential core outcomes to inform the development of recommendations for future core coutcome set developers. Design: Mixed methods study. Setting: A core outcome set for pre-eclampsia was used as an exemplar. Sample: A long list of potential core outcomes was developed by undertaking a systematic review of pre-eclampsia trials and performing a thematic analysis of in-depth patient interviews. Methods: Specific methods used to generate long lists of potential core outcomes were evaluated. Results: Different methodological decisions had a substantial impact on the identification of potential core outcomes. Extracting outcomes from published pre-eclampsia trials was an effective way of identifying 48 maternal, eight fetal, 25 neonatal outcomes, and eight patient-reported outcomes. Limiting the extraction of outcomes to primary outcomes or outcomes commonly reported in pre-eclampsia trials reduced the number and diversity of potential core outcomes identified. Thematic analysis of in-depth patient interviews ensured an additional five patient reported outcomes and six outcomes related to future child health were identified. Conclusions: Future core outcome set developers should use quantitative and qualitative methods when developing a long list of potential core outcomes. Tweetable abstract: @OfficialNIHR research published in @BJOGtweets informs new recommendations for future @coreoutcomes developers.
KW - Core outcome sets
KW - outcomes
KW - pre-eclampsia
KW - qualitative interviews
KW - systematic review
UR - http://www.scopus.com/inward/record.url?scp=85071746150&partnerID=8YFLogxK
U2 - 10.1111/1471-0528.15892
DO - 10.1111/1471-0528.15892
M3 - Article
C2 - 31359560
AN - SCOPUS:85071746150
SN - 1470-0328
VL - 126
SP - 1482
EP - 1490
JO - BJOG: An International Journal of Obstetrics and Gynaecology
JF - BJOG: An International Journal of Obstetrics and Gynaecology
IS - 12
ER -