Methodological Considerations for Selection of Transcranial Direct Current Stimulation Approach, Protocols and Devices

Shapour Jaberzadeh, Donel Martin, Helena Knotkova, Adam J. Woods

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review


This chapter describes the methodological considerations for selection of transcranial direct current stimulation (tDCS) approaches, protocols and devices for studies conducted in both healthy individuals and patients with different pathological conditions. The first section of the chapter discusses evidence-based use of tDCS. The second section of the chapter describes tDCS as a neuroscience research tool, which is used for better understanding of the neural substrates of performance on cognitive, sensory and motor tasks. A brief description of blinding and sham procedure in tDCS studies is also provided in this chapter. The third section of this chapter briefly describes methodological considerations in relation to clinical use of tDCS as a stand-alone or adjunctive technique to prime the effects of other interventions for the treatment of psychological and neurological disorders and pain management. In this section, contributions of tDCS research to evidence-based medicine will also be discussed. The final section of this chapter provides a decision diagram that outlines the following nine parameters associated with selection of tDCS protocols: (1) Goals of tDCS, (2) Characteristics of applied current, (3) Electrode size, (4) Stimulation site, (5) Montage selection, (6) tDCS devices, (7) Single-site versus multi-site stimulation, (8) Frequency of tDCS application, (9) Targeted population. A brief conclusion will be provided at the end of chapter.
Original languageEnglish
Title of host publicationPractical Guide to Transcranial Direct Current Stimulation
Subtitle of host publicationPrinciples, Procedures and Applications
EditorsHelena Knotkova, Michael A. Nitsche, Marom Bikson, Adam J. Woods
Place of PublicationCham, Switzerland
Number of pages25
ISBN (Electronic)9783319959481
ISBN (Print)9783319959474
Publication statusPublished - 24 Jan 2019

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