TY - JOUR
T1 - Methicillin-susceptible Staphylococcus aureus endocarditis isolates are associated with clonal complex 30 genotype and a distinct repertoire of enterotoxins and adhesins
AU - Nienaber, Juhsien
AU - Kuinkel, Batu
AU - Clarke-Pearson, Michael
AU - Lamlertthon, Supaporn
AU - Park, Lawrence
AU - Rude, Thomas
AU - Barriere, Steve
AU - Woods, Christopher
AU - Chu, Vivian
AU - Marin, Mercedes
AU - Bukovski, Suzana
AU - Garcia, Patricia
AU - Corey, G R
AU - Korman, Tony
AU - Doco-Lecompte, Thanh
AU - Murdoch, David
AU - Reller, Barth
AU - Fowler, Vance
PY - 2011
Y1 - 2011
N2 - Using multinational collections of methicillin-susceptible Staphylococcus aureus (MSSA) isolates from infective endocarditis (IE) and soft tissue infections (STIs), we sought to (1) validate the finding that S. aureus in clonal complex (CC) 30 is associated with hematogenous complications and (2) test the hypothesis that specific genetic characteristics in S. aureus are associated with infection severity. METHODS: IE and STI isolates from 2 cohorts were frequency matched by geographic origin. Isolates underwent spa typing to infer CC and multiplex polymerase chain reaction for presence of virulence genes. RESULTS: 114 isolate pairs were genotyped. IE isolates were more likely to be CC30 (19.5 vs 6.2 ; P = .005) and to contain 3 adhesins (clfB, cna, map/eap; P <.0001 for all) and 5 enterotoxins (tst, sea, sed, see, and sei; P
AB - Using multinational collections of methicillin-susceptible Staphylococcus aureus (MSSA) isolates from infective endocarditis (IE) and soft tissue infections (STIs), we sought to (1) validate the finding that S. aureus in clonal complex (CC) 30 is associated with hematogenous complications and (2) test the hypothesis that specific genetic characteristics in S. aureus are associated with infection severity. METHODS: IE and STI isolates from 2 cohorts were frequency matched by geographic origin. Isolates underwent spa typing to infer CC and multiplex polymerase chain reaction for presence of virulence genes. RESULTS: 114 isolate pairs were genotyped. IE isolates were more likely to be CC30 (19.5 vs 6.2 ; P = .005) and to contain 3 adhesins (clfB, cna, map/eap; P <.0001 for all) and 5 enterotoxins (tst, sea, sed, see, and sei; P
UR - http://jid.oxfordjournals.org/content/204/5/704.full.pdf+html
U2 - 10.1093/infdis/jir389
DO - 10.1093/infdis/jir389
M3 - Article
VL - 204
SP - 704
EP - 713
JO - The Journal of Infectious Diseases
JF - The Journal of Infectious Diseases
SN - 0022-1899
IS - 5
ER -