Metalloproteolytic receptor shedding…platelets “acting their age”

Robert K. Andrews, Elizabeth E. Gardiner

Research output: Contribution to journalReview ArticleOtherpeer-review

10 Citations (Scopus)

Abstract

Whilst significant effort has been focused on development of tools and approaches to clinically modulate activation processes that consume platelets, the platelet receptors that initiate activation processes remain untargeted. The modulation of receptor levels is also linked to underlying platelet aging processes which influence normal platelet lifespan and also the functionality and survival of stored platelets that are used in transfusion. In this review, we will focus on platelet adhesion receptors initiating thrombus formation, and discuss how regulation of levels of these receptors impact platelet function and platelet survival.

Original languageEnglish
Pages (from-to)512-518
Number of pages7
JournalPlatelets
Volume27
Issue number6
DOIs
Publication statusPublished - 17 Aug 2016

Keywords

  • Glycoprotein
  • metalloproteinase
  • platelet
  • thrombocytopenia

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