Abstract
In this article, we report the design, synthesis,
biological activity, and selected ADME properties for a library
of novel metallocene-based CA inhibitors. The development of
metallocene-based compounds that can selectively kill tumor
cells by inhibiting the validated oncology target CA IX is a new
approach with potential to deliver organometallic, drug-like
compounds as future therapies.
Original language | English |
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Pages (from-to) | 5506 - 5517 |
Number of pages | 12 |
Journal | Journal of Medicinal Chemistry |
Volume | 55 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2012 |