Metallocene-based inhibitors of cancer-associated carbonic anhydrase enzymes IX and XII

Adam J Salmon, Michael L Williams, Quoc Kien Wu, Julia Morizzi, Daniel John Gregg, Susan Ann Charman, D Vullo, Claudiu Trandafir Supuran, Sally-Ann Poulsen

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)


In this article, we report the design, synthesis, biological activity, and selected ADME properties for a library of novel metallocene-based CA inhibitors. The development of metallocene-based compounds that can selectively kill tumor cells by inhibiting the validated oncology target CA IX is a new approach with potential to deliver organometallic, drug-like compounds as future therapies.
Original languageEnglish
Pages (from-to)5506 - 5517
Number of pages12
JournalJournal of Medicinal Chemistry
Issue number11
Publication statusPublished - 2012

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