Metal Compounds against Neglected Tropical Diseases

Yih Ching Ong, Saonli Roy, Philip C. Andrews, Gilles Gasser

Research output: Contribution to journalReview ArticleResearchpeer-review

30 Citations (Scopus)

Abstract

Many first-line treatments for neglected tropical diseases identified by the World Health Organization (WHO) are limited by one or more of the following: the development of drug resistance, toxicity, and side effects, lack of selectivity, narrow therapeutic indices, route of administration, and bioavailability. As such, there is an urgent need to develop viable alternatives to overcome these limitations. The following review provides an overview of all existing metal complexes studied and evaluates the status of these complexes on the respective disease of choice.

Original languageEnglish
Pages (from-to)730-796
Number of pages67
JournalChemical Reviews
Volume119
Issue number2
DOIs
Publication statusPublished - 23 Jan 2019

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