Metal clips that induce unstructured pentapeptides to be alpha-helical in water

Michelle Ma, Huy Hoang, Conor Scully, Trevor Appleton, David Fairlie

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Abstract

Short peptides corresponding to protein helices do not form thermodynamically stable helical structures in water, a solvent that strongly competes for hydrogen-bonding amides of the peptide backbone. Metalloproteins often feature metal ions coordinated to amino acids within hydrogen-bonded helical regions of protein structure, so there is a prospect of metals stabilizing or inducing helical structures in short peptides. However, this has only previously been observed in nonaqueous solvents or under strongly helix-favoring conditions in water
Original languageEnglish
Pages (from-to)4505 - 4512
Number of pages8
JournalJournal of the American Chemical Society
Volume131
Issue number12
DOIs
Publication statusPublished - 2009
Externally publishedYes

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