Metal Acetylide Elimination: The Key Step in the Cascade Decomposition and Transformation of Metalated Propargylamines

Matthew T. Flynn; Victoria L. Blair; Philip C. Andrews

doi:10.1021/acs.organomet.8b00047

Metal Acetylide Elimination: The Key Step in the Cascade Decomposition and Transformation of Metalated Propargylamines

Matthew T. Flynn, Victoria L. Blair, Philip C. Andrews

School of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

Metal acetylide elimination facilitates a novel one-pot cascade metalation and elimination/addition route to a series of unsymmetrical secondary amines from the reaction of secondary propargylamines with organometallic reagents. Spectroscopic evidence suggests a dimetalated amido intermediate rather than an allene.

Original language	English
Pages (from-to)	1225-1228
Number of pages	4
Journal	Organometallics
Volume	37
Issue number	8
DOIs	https://doi.org/10.1021/acs.organomet.8b00047
Publication status	Published - 23 Apr 2018

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10.1021/acs.organomet.8b00047

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title = "Metal Acetylide Elimination: The Key Step in the Cascade Decomposition and Transformation of Metalated Propargylamines",

abstract = "Metal acetylide elimination facilitates a novel one-pot cascade metalation and elimination/addition route to a series of unsymmetrical secondary amines from the reaction of secondary propargylamines with organometallic reagents. Spectroscopic evidence suggests a dimetalated amido intermediate rather than an allene.",

author = "Flynn, \{Matthew T.\} and Blair, \{Victoria L.\} and Andrews, \{Philip C.\}",

year = "2018",

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language = "English",

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AU - Flynn, Matthew T.

AU - Blair, Victoria L.

AU - Andrews, Philip C.

PY - 2018/4/23

Y1 - 2018/4/23

N2 - Metal acetylide elimination facilitates a novel one-pot cascade metalation and elimination/addition route to a series of unsymmetrical secondary amines from the reaction of secondary propargylamines with organometallic reagents. Spectroscopic evidence suggests a dimetalated amido intermediate rather than an allene.

AB - Metal acetylide elimination facilitates a novel one-pot cascade metalation and elimination/addition route to a series of unsymmetrical secondary amines from the reaction of secondary propargylamines with organometallic reagents. Spectroscopic evidence suggests a dimetalated amido intermediate rather than an allene.

UR - https://www.scopus.com/pages/publications/85045932876

U2 - 10.1021/acs.organomet.8b00047

DO - 10.1021/acs.organomet.8b00047

M3 - Article

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JO - Organometallics

JF - Organometallics

IS - 8

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Metal Acetylide Elimination: The Key Step in the Cascade Decomposition and Transformation of Metalated Propargylamines

Abstract

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Expanding the Organometallic Toolbox for Constructing Novel Heterocycles

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Metal Acetylide Elimination: The Key Step in the Cascade Decomposition and Transformation of Metalated Propargylamines

Abstract

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Projects

Expanding the Organometallic Toolbox for Constructing Novel Heterocycles

Cite this