Metabolomic analysis of trypanosomatid protozoa

Darren John Creek, Jana Simon Anderson, Malcolm J McConville, Michael P Barrett

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44 Citations (Scopus)

Abstract

Metabolomics aims to measure all low molecular weight chemicals within a given system in a manner analogous to transcriptomics, proteomics and genomics. In this review we highlight metabolomics approaches that are currently being applied to the kinetoplastid parasites, Trypanosoma brucei and Leishmania spp. The use of untargeted metabolomics approaches, made possible through advances in mass spectrometry and informatics, and stable isotope labelling has increased our understanding of the metabolism in these organisms beyond the views established using classical biochemical approaches. Set within the context of metabolic networks, predicted using genome-wide reconstructions of metabolism, new hypotheses on how to target aspects of metabolism to design new drugs against these protozoa are emerging.
Original languageEnglish
Pages (from-to)73 - 84
Number of pages12
JournalMolecular and Biochemical Parasitology
Volume181
Issue number2
DOIs
Publication statusPublished - 2012
Externally publishedYes

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