Metabolism and urinary excretion of benzhexol in humans

R. L. Nation, E. J. Triggs, J. Vine

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Abstract

1. Benzhexol and three of its metabolites excreted in urine in man have been investigated by g.l.c.-mass spectrometry. 2. Three isomeric hydroxylated metabolites were identified as the 1-(hydroxycyclohexyl)-1-phenyl-3-piperidinopropan-1-ols. 3. The amounts of benzhexol and its identified metabolites have been semiquantitatively determined after a single oral dose in two healthy adults. Approx. 56% of the dose was excreted as the hydroxylated metabolites. The levels of benzhexol excreted were too low to be measured by the techniques used.

Original languageEnglish
Pages (from-to)165-169
Number of pages5
JournalXenobiotica
Volume8
Issue number3
DOIs
Publication statusPublished - 1 Jan 1978
Externally publishedYes

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