TY - JOUR
T1 - Metabolic risk in PCOS
T2 - Phenotype and adiposity impact
AU - Moran, Lisa J.
AU - Norman, Robert J.
AU - Teede, Helena J.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Polycystic ovary syndrome (PCOS) is a common condition in reproductive-aged women, with reproductive, cardiometabolic, and psychological features. The heterogeneity in insulin resistance, obesity, and cardiometabolic features has led to controversy on the independent contributions of PCOS status, diagnostic criteria, phenotype, and adiposity. It now appears that women with PCOS have an increased risk of insulin resistance and cardiometabolic features, which is independent of, but worsened by, adiposity and central adiposity, and is unrelated to reproductive phenotype. Obesity may be more prevalent in the more severe phenotypes, which suggests either an exacerbation of the reproductive features or a more likely diagnosis in overweight women with PCOS. Therefore, all women with PCOS should be targeted for prevention, screening, and management of cardiometabolic features.
AB - Polycystic ovary syndrome (PCOS) is a common condition in reproductive-aged women, with reproductive, cardiometabolic, and psychological features. The heterogeneity in insulin resistance, obesity, and cardiometabolic features has led to controversy on the independent contributions of PCOS status, diagnostic criteria, phenotype, and adiposity. It now appears that women with PCOS have an increased risk of insulin resistance and cardiometabolic features, which is independent of, but worsened by, adiposity and central adiposity, and is unrelated to reproductive phenotype. Obesity may be more prevalent in the more severe phenotypes, which suggests either an exacerbation of the reproductive features or a more likely diagnosis in overweight women with PCOS. Therefore, all women with PCOS should be targeted for prevention, screening, and management of cardiometabolic features.
KW - Cardiometabolic
KW - Diagnostic criteria
KW - Insulin resistance
KW - Obesity
KW - Polycystic ovary syndrome
UR - http://www.scopus.com/inward/record.url?scp=84923570421&partnerID=8YFLogxK
U2 - 10.1016/j.tem.2014.12.003
DO - 10.1016/j.tem.2014.12.003
M3 - Review Article
C2 - 25591984
AN - SCOPUS:84923570421
SN - 1043-2760
VL - 26
SP - 136
EP - 143
JO - Trends in Endocrinology & Metabolism
JF - Trends in Endocrinology & Metabolism
IS - 3
ER -