Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality

Tao Huang, Ying Chen, Bin Yang, Jing Yang, Mark L. Wahlqvist, Duo Li

Research output: Contribution to journalReview ArticleResearchpeer-review

77 Citations (Scopus)

Abstract

Background & aims: Results from randomized controlled trials (RCT) of B vitamin supplementation on risk of cardiovascular disease (CVD) were inconclusive. The aim of the present study was to systematically review the effects of B vitamin supplementation on plasma homocysteine (Hcy), cardiovascular and all-cause mortality in RCT. Methods: RCT publications on the effect of B vitamin supplementation on plasma Hcy, cardiovascular and all-cause mortality were searched from PubMed and web of science database. Data were independently abstracted by 2 investigators using a standardized protocol. The results were pooled with a fixed-effects model using Stata software. Results: Data from 19 studies including 47921participants were analyzed using a fixed-effects model. The overall relative risks with 95% confidence intervals of outcomes for patients treated with B vitamin supplementation compared with placebo were 0.98 (0.94-1.03) for CVD, 0.98 (0.92-1.05) for coronary heart disease (CHD), 0.97 (0.90-1.05) for myocardial infarction (MI), 0.88 (0.82-0.95) for stroke, and 0.97 (0.91-1.02) for cardiovascular death, 0.99 (0.95-1.04) for all-cause mortality. Blood Hcy levels were decreased in all included RCTs. Conclusions: B vitamin supplementation has a significant protective effect on stroke, but none on the risk of CVD, MI, CHD, cardiovascular death, or all-cause mortality.

Original languageEnglish
Pages (from-to)448-454
Number of pages7
JournalClinical Nutrition
Volume31
Issue number4
DOIs
Publication statusPublished - Aug 2012

Keywords

  • All-cause mortality
  • B vitamin
  • Cardiovascular disease
  • Plasma homocysteine
  • RCT

Cite this

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title = "Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality",
abstract = "Background & aims: Results from randomized controlled trials (RCT) of B vitamin supplementation on risk of cardiovascular disease (CVD) were inconclusive. The aim of the present study was to systematically review the effects of B vitamin supplementation on plasma homocysteine (Hcy), cardiovascular and all-cause mortality in RCT. Methods: RCT publications on the effect of B vitamin supplementation on plasma Hcy, cardiovascular and all-cause mortality were searched from PubMed and web of science database. Data were independently abstracted by 2 investigators using a standardized protocol. The results were pooled with a fixed-effects model using Stata software. Results: Data from 19 studies including 47921participants were analyzed using a fixed-effects model. The overall relative risks with 95{\%} confidence intervals of outcomes for patients treated with B vitamin supplementation compared with placebo were 0.98 (0.94-1.03) for CVD, 0.98 (0.92-1.05) for coronary heart disease (CHD), 0.97 (0.90-1.05) for myocardial infarction (MI), 0.88 (0.82-0.95) for stroke, and 0.97 (0.91-1.02) for cardiovascular death, 0.99 (0.95-1.04) for all-cause mortality. Blood Hcy levels were decreased in all included RCTs. Conclusions: B vitamin supplementation has a significant protective effect on stroke, but none on the risk of CVD, MI, CHD, cardiovascular death, or all-cause mortality.",
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Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality. / Huang, Tao; Chen, Ying; Yang, Bin; Yang, Jing; Wahlqvist, Mark L.; Li, Duo.

In: Clinical Nutrition, Vol. 31, No. 4, 08.2012, p. 448-454.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Meta-analysis of B vitamin supplementation on plasma homocysteine, cardiovascular and all-cause mortality

AU - Huang, Tao

AU - Chen, Ying

AU - Yang, Bin

AU - Yang, Jing

AU - Wahlqvist, Mark L.

AU - Li, Duo

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N2 - Background & aims: Results from randomized controlled trials (RCT) of B vitamin supplementation on risk of cardiovascular disease (CVD) were inconclusive. The aim of the present study was to systematically review the effects of B vitamin supplementation on plasma homocysteine (Hcy), cardiovascular and all-cause mortality in RCT. Methods: RCT publications on the effect of B vitamin supplementation on plasma Hcy, cardiovascular and all-cause mortality were searched from PubMed and web of science database. Data were independently abstracted by 2 investigators using a standardized protocol. The results were pooled with a fixed-effects model using Stata software. Results: Data from 19 studies including 47921participants were analyzed using a fixed-effects model. The overall relative risks with 95% confidence intervals of outcomes for patients treated with B vitamin supplementation compared with placebo were 0.98 (0.94-1.03) for CVD, 0.98 (0.92-1.05) for coronary heart disease (CHD), 0.97 (0.90-1.05) for myocardial infarction (MI), 0.88 (0.82-0.95) for stroke, and 0.97 (0.91-1.02) for cardiovascular death, 0.99 (0.95-1.04) for all-cause mortality. Blood Hcy levels were decreased in all included RCTs. Conclusions: B vitamin supplementation has a significant protective effect on stroke, but none on the risk of CVD, MI, CHD, cardiovascular death, or all-cause mortality.

AB - Background & aims: Results from randomized controlled trials (RCT) of B vitamin supplementation on risk of cardiovascular disease (CVD) were inconclusive. The aim of the present study was to systematically review the effects of B vitamin supplementation on plasma homocysteine (Hcy), cardiovascular and all-cause mortality in RCT. Methods: RCT publications on the effect of B vitamin supplementation on plasma Hcy, cardiovascular and all-cause mortality were searched from PubMed and web of science database. Data were independently abstracted by 2 investigators using a standardized protocol. The results were pooled with a fixed-effects model using Stata software. Results: Data from 19 studies including 47921participants were analyzed using a fixed-effects model. The overall relative risks with 95% confidence intervals of outcomes for patients treated with B vitamin supplementation compared with placebo were 0.98 (0.94-1.03) for CVD, 0.98 (0.92-1.05) for coronary heart disease (CHD), 0.97 (0.90-1.05) for myocardial infarction (MI), 0.88 (0.82-0.95) for stroke, and 0.97 (0.91-1.02) for cardiovascular death, 0.99 (0.95-1.04) for all-cause mortality. Blood Hcy levels were decreased in all included RCTs. Conclusions: B vitamin supplementation has a significant protective effect on stroke, but none on the risk of CVD, MI, CHD, cardiovascular death, or all-cause mortality.

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SN - 0261-5614

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