Met-enkephalin binding to opiate receptors is not functionally coupled to biodegradation

András Nagy, László Gráff, Abel Lajtha

Research output: Contribution to journalArticleResearchpeer-review


Using synaptosomal rat brain membranes, the degradation of Met-enkephalin in both free and receptor-bound form was measured, together with the dissociation of Met-enkephalin from the receptors. The results show that the degradation rate of initially receptor-bound Met-enkephalin is significantly smaller than either the rate of dissociation from the receptors or that of the degradation of free Met-enkephalin. These data suggest that intact Met-enkephalin dissociates from the receptors and then it becomes a target for the same membrane-associated peptidases that split free Met-enkephalin. This view is supported by the good fitness of the measured degradation of initially receptor-bound Met-enkephalin to the predicted degradation curve calculated from the dissociation rate of receptor-bound Met-enkephalin and the degradation rate of free Met-enkephalin.

Original languageEnglish
Pages (from-to)835-840
Number of pages6
JournalLife Sciences
Issue number9
Publication statusPublished - 29 Aug 1983
Externally publishedYes

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