Mesenchymal stem/stromal cells in post-menopausal endometrium

Daniela Ulrich, Ker Sin Tan, James Antony Deane, Kjiana Elkje Schwab, Amy Cheong, Anna Rosamilia, Caroline Eve Gargett

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41 Citations (Scopus)

Abstract

STUDY QUESTION: Does post-menopausal endometrium contain mesenchymal stem/stromal cells (MSC) that have adult stem cell properties and can be prospectively isolated from a biopsy? SUMMARY ANSWER: Perivascular W5C5(+) cells isolated from post-menopausal endometrial biopsies displayed characteristic MSC properties of clonogenicity, multipotency and surface phenotype irrespective of whether the women were or were not pre-treated with estrogen to regenerate the endometrium. WHAT IS KNOWN ALREADY: Recently MSCs have been identified in human premenopausal endometrium, and can be prospectively isolated using a single marker, W5C5/SUSD2. STUDY DESIGN, SIZE, DURATION: Endometrial tissue of both the functional and basal layers, from 17 premenopausal (pre-MP) women, 19 post-menopausal (post-MP) women without hormonal treatment and 15 post-menopausal women on estrogen replacement therapy (post-MP+ E2), was collected through a prospective phase IV clinical trial over 2 years. PARTICIPANTS/MATERIALS, SETTING, METHODS: Post-menopausal women
Original languageEnglish
Pages (from-to)1895 - 1905
Number of pages11
JournalHuman Reproduction
Volume29
Issue number9
DOIs
Publication statusPublished - 2014

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