Mesenchymal Stem Cells for Treatment of CNS Injury

Michael Azari, Louisa Mathias, Ezgi Ozturk, David Cram, Richard Boyd, Steven Petratos

    Research output: Contribution to journalArticleResearchpeer-review

    51 Citations (Scopus)

    Abstract

    Brain and spinal cord injuries present significant therapeutic challenges. The treatments available for these conditions are largely ineffective, partly due to limitations in directly targeting the therapeutic agents to sites of pathology within the central nervous system (CNS). The use of stem cells to treat these conditions presents a novel therapeutic strategy. A variety of stem cell treatments have been examined in animal models of CNS trauma. Many of these studies have used stem cells as a cell-replacement strategy. These investigations have also highlighted the significant limitations of this approach. Another potential strategy for stem cell therapy utilises stem cells as a delivery mechanism for therapeutic molecules. This review surveys the literature relevant to the potential of mesenchymal stem cells for delivery of therapeutic agents in CNS trauma in humans.
    Original languageEnglish
    Pages (from-to)316 - 323
    Number of pages8
    JournalCurrent Neuropharmacology
    Volume8
    DOIs
    Publication statusPublished - 2010

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