Mesenchymal stem cells and cell therapy for bone repair

Shihua Wang, Pengchao Xu, Xiaoxia Li, Xiaodong Su, Yunfei Chen, Li Wan, Linyuan Fan, Kan Yin, Yan Liu, Robert Chunhua Zhao

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) represent a new therapeutic paradigm for a number of diseases because they possess unique biological characteristics such as multipotency, immunomodulation and production of cytokines. Currently, 425 MSC based clinical trials have been conducted for at least 12 kinds of pathological conditions, with many completed trials demonstrating the safety and efficacy of MSCs. Here, we provide an overview of the clinical status of MSCs by searching the public clinical trials database http://clinicaltrials.gov. Particularly, the role of MSCs in clinical trials to treat bone defects and injuries is highlighted.

Original languageEnglish
Pages (from-to)289-299
Number of pages11
JournalCurrent Molecular Pharmacology
Volume9
Issue number4
DOIs
Publication statusPublished - 1 Nov 2016
Externally publishedYes

Keywords

  • Bone defects
  • Clinical transition
  • Differentiation
  • Immunomodulation
  • Mesenchymal stem cells
  • Secretome

Cite this

Wang, S., Xu, P., Li, X., Su, X., Chen, Y., Wan, L., Fan, L., Yin, K., Liu, Y., & Zhao, R. C. (2016). Mesenchymal stem cells and cell therapy for bone repair. Current Molecular Pharmacology, 9(4), 289-299. https://doi.org/10.2174/1874467208666150928153758