Mesenchymal stem cells and cell therapy for bone repair

Shihua Wang; Pengchao Xu; Xiaoxia Li; Xiaodong Su; Yunfei Chen; Li Wan; Linyuan Fan; Kan Yin; Yan Liu; Robert Chunhua Zhao

doi:10.2174/1874467208666150928153758

Mesenchymal stem cells and cell therapy for bone repair

Shihua Wang, Pengchao Xu, Xiaoxia Li, Xiaodong Su, Yunfei Chen, Li Wan, Linyuan Fan, Kan Yin, Yan Liu, Robert Chunhua Zhao

Research output: Contribution to journal › Review Article › Research › peer-review

5 Citations (Scopus)

Abstract

Mesenchymal stem cells (MSCs) represent a new therapeutic paradigm for a number of diseases because they possess unique biological characteristics such as multipotency, immunomodulation and production of cytokines. Currently, 425 MSC based clinical trials have been conducted for at least 12 kinds of pathological conditions, with many completed trials demonstrating the safety and efficacy of MSCs. Here, we provide an overview of the clinical status of MSCs by searching the public clinical trials database http://clinicaltrials.gov. Particularly, the role of MSCs in clinical trials to treat bone defects and injuries is highlighted.

Original language	English
Pages (from-to)	289-299
Number of pages	11
Journal	Current Molecular Pharmacology
Volume	9
Issue number	4
DOIs	https://doi.org/10.2174/1874467208666150928153758
Publication status	Published - 1 Nov 2016
Externally published	Yes

Keywords

Bone defects
Clinical transition
Differentiation
Immunomodulation
Mesenchymal stem cells
Secretome

Access to Document

10.2174/1874467208666150928153758

59245817-oaFinal published version, 2.72 MB

Cite this

@article{8ff76ae4c32b460795d8de379991e1c0,

title = "Mesenchymal stem cells and cell therapy for bone repair",

abstract = "Mesenchymal stem cells (MSCs) represent a new therapeutic paradigm for a number of diseases because they possess unique biological characteristics such as multipotency, immunomodulation and production of cytokines. Currently, 425 MSC based clinical trials have been conducted for at least 12 kinds of pathological conditions, with many completed trials demonstrating the safety and efficacy of MSCs. Here, we provide an overview of the clinical status of MSCs by searching the public clinical trials database http://clinicaltrials.gov. Particularly, the role of MSCs in clinical trials to treat bone defects and injuries is highlighted.",

keywords = "Bone defects, Clinical transition, Differentiation, Immunomodulation, Mesenchymal stem cells, Secretome",

author = "Shihua Wang and Pengchao Xu and Xiaoxia Li and Xiaodong Su and Yunfei Chen and Li Wan and Linyuan Fan and Kan Yin and Yan Liu and Zhao, {Robert Chunhua}",

year = "2016",

month = nov,

day = "1",

doi = "10.2174/1874467208666150928153758",

language = "English",

volume = "9",

pages = "289--299",

journal = "Current Molecular Pharmacology",

issn = "1874-4672",

publisher = "Bentham Science Publishers",

number = "4",

}

TY - JOUR

T1 - Mesenchymal stem cells and cell therapy for bone repair

AU - Wang, Shihua

AU - Xu, Pengchao

AU - Li, Xiaoxia

AU - Su, Xiaodong

AU - Chen, Yunfei

AU - Wan, Li

AU - Fan, Linyuan

AU - Yin, Kan

AU - Liu, Yan

AU - Zhao, Robert Chunhua

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Mesenchymal stem cells (MSCs) represent a new therapeutic paradigm for a number of diseases because they possess unique biological characteristics such as multipotency, immunomodulation and production of cytokines. Currently, 425 MSC based clinical trials have been conducted for at least 12 kinds of pathological conditions, with many completed trials demonstrating the safety and efficacy of MSCs. Here, we provide an overview of the clinical status of MSCs by searching the public clinical trials database http://clinicaltrials.gov. Particularly, the role of MSCs in clinical trials to treat bone defects and injuries is highlighted.

AB - Mesenchymal stem cells (MSCs) represent a new therapeutic paradigm for a number of diseases because they possess unique biological characteristics such as multipotency, immunomodulation and production of cytokines. Currently, 425 MSC based clinical trials have been conducted for at least 12 kinds of pathological conditions, with many completed trials demonstrating the safety and efficacy of MSCs. Here, we provide an overview of the clinical status of MSCs by searching the public clinical trials database http://clinicaltrials.gov. Particularly, the role of MSCs in clinical trials to treat bone defects and injuries is highlighted.

KW - Bone defects

KW - Clinical transition

KW - Differentiation

KW - Immunomodulation

KW - Mesenchymal stem cells

KW - Secretome

UR - http://www.scopus.com/inward/record.url?scp=84995968126&partnerID=8YFLogxK

U2 - 10.2174/1874467208666150928153758

DO - 10.2174/1874467208666150928153758

M3 - Review Article

AN - SCOPUS:84995968126

VL - 9

SP - 289

EP - 299

JO - Current Molecular Pharmacology

JF - Current Molecular Pharmacology

SN - 1874-4672

IS - 4

ER -

Mesenchymal stem cells and cell therapy for bone repair

Abstract

Keywords

Access to Document

Other files and links

Cite this