Mesenchymal stem cell tracking in the intervertebral disc

Charles Handley, Anthony Goldschlager, David Oehme, Peter Ghosh, Graham Jenkin

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Low back pain is a common clinical problem, which leads to significant social, economic and public health costs. Intervertebral disc (IVD) degeneration is accepted as a common cause of low back pain. Initially, this is characterized by a loss of proteoglycans from the nucleus pulposus resulting in loss of tissue hydration and hydrostatic pressure. Conservative management, including analgesia and physiotherapy often fails and surgical treatment, such as spinal fusion, is required. Stem cells offer an exciting possible regenerative approach to IVD disease. Preclinical research has demonstrated promising biochemical, histological and radiological results in restoring degenerate IVDs. Cell tracking provides an opportunity to develop an in-depth understanding of stem cell survival, differentiation and migration, enabling optimization of stem cell treatment. Magnetic Resonance Imaging (MRI) is a non-invasive, non-ionizing imaging modality with high spatial resolution, ideally suited for stem cell tracking. Furthermore, novel MRI sequences have the potential to quantitatively assess IVD disease, providing an improved method to review response to biological treatment. Superparamagnetic iron oxide nanoparticles have been extensively researched for the purpose of cell tracking. These particles are biocompatible, non-toxic and act as excellent MRI contrast agents. This review will explore recent advances and issues in stem cell tracking and molecular imaging in relation to the IVD.
Original languageEnglish
Pages (from-to)65 - 74
Number of pages10
JournalWorld Journal of Stem Cells
Volume7
Issue number1
DOIs
Publication statusPublished - 2015

Cite this

Handley, Charles ; Goldschlager, Anthony ; Oehme, David ; Ghosh, Peter ; Jenkin, Graham. / Mesenchymal stem cell tracking in the intervertebral disc. In: World Journal of Stem Cells. 2015 ; Vol. 7, No. 1. pp. 65 - 74.
@article{dbee264c32ef4f93a956908217ad74f1,
title = "Mesenchymal stem cell tracking in the intervertebral disc",
abstract = "Low back pain is a common clinical problem, which leads to significant social, economic and public health costs. Intervertebral disc (IVD) degeneration is accepted as a common cause of low back pain. Initially, this is characterized by a loss of proteoglycans from the nucleus pulposus resulting in loss of tissue hydration and hydrostatic pressure. Conservative management, including analgesia and physiotherapy often fails and surgical treatment, such as spinal fusion, is required. Stem cells offer an exciting possible regenerative approach to IVD disease. Preclinical research has demonstrated promising biochemical, histological and radiological results in restoring degenerate IVDs. Cell tracking provides an opportunity to develop an in-depth understanding of stem cell survival, differentiation and migration, enabling optimization of stem cell treatment. Magnetic Resonance Imaging (MRI) is a non-invasive, non-ionizing imaging modality with high spatial resolution, ideally suited for stem cell tracking. Furthermore, novel MRI sequences have the potential to quantitatively assess IVD disease, providing an improved method to review response to biological treatment. Superparamagnetic iron oxide nanoparticles have been extensively researched for the purpose of cell tracking. These particles are biocompatible, non-toxic and act as excellent MRI contrast agents. This review will explore recent advances and issues in stem cell tracking and molecular imaging in relation to the IVD.",
author = "Charles Handley and Anthony Goldschlager and David Oehme and Peter Ghosh and Graham Jenkin",
year = "2015",
doi = "10.4252/wjsc.v7.i1.65",
language = "English",
volume = "7",
pages = "65 -- 74",
journal = "World Journal of Stem Cells",
issn = "1948-0210",
publisher = "Baishideng Publishing Group",
number = "1",

}

Mesenchymal stem cell tracking in the intervertebral disc. / Handley, Charles; Goldschlager, Anthony; Oehme, David; Ghosh, Peter; Jenkin, Graham.

In: World Journal of Stem Cells, Vol. 7, No. 1, 2015, p. 65 - 74.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Mesenchymal stem cell tracking in the intervertebral disc

AU - Handley, Charles

AU - Goldschlager, Anthony

AU - Oehme, David

AU - Ghosh, Peter

AU - Jenkin, Graham

PY - 2015

Y1 - 2015

N2 - Low back pain is a common clinical problem, which leads to significant social, economic and public health costs. Intervertebral disc (IVD) degeneration is accepted as a common cause of low back pain. Initially, this is characterized by a loss of proteoglycans from the nucleus pulposus resulting in loss of tissue hydration and hydrostatic pressure. Conservative management, including analgesia and physiotherapy often fails and surgical treatment, such as spinal fusion, is required. Stem cells offer an exciting possible regenerative approach to IVD disease. Preclinical research has demonstrated promising biochemical, histological and radiological results in restoring degenerate IVDs. Cell tracking provides an opportunity to develop an in-depth understanding of stem cell survival, differentiation and migration, enabling optimization of stem cell treatment. Magnetic Resonance Imaging (MRI) is a non-invasive, non-ionizing imaging modality with high spatial resolution, ideally suited for stem cell tracking. Furthermore, novel MRI sequences have the potential to quantitatively assess IVD disease, providing an improved method to review response to biological treatment. Superparamagnetic iron oxide nanoparticles have been extensively researched for the purpose of cell tracking. These particles are biocompatible, non-toxic and act as excellent MRI contrast agents. This review will explore recent advances and issues in stem cell tracking and molecular imaging in relation to the IVD.

AB - Low back pain is a common clinical problem, which leads to significant social, economic and public health costs. Intervertebral disc (IVD) degeneration is accepted as a common cause of low back pain. Initially, this is characterized by a loss of proteoglycans from the nucleus pulposus resulting in loss of tissue hydration and hydrostatic pressure. Conservative management, including analgesia and physiotherapy often fails and surgical treatment, such as spinal fusion, is required. Stem cells offer an exciting possible regenerative approach to IVD disease. Preclinical research has demonstrated promising biochemical, histological and radiological results in restoring degenerate IVDs. Cell tracking provides an opportunity to develop an in-depth understanding of stem cell survival, differentiation and migration, enabling optimization of stem cell treatment. Magnetic Resonance Imaging (MRI) is a non-invasive, non-ionizing imaging modality with high spatial resolution, ideally suited for stem cell tracking. Furthermore, novel MRI sequences have the potential to quantitatively assess IVD disease, providing an improved method to review response to biological treatment. Superparamagnetic iron oxide nanoparticles have been extensively researched for the purpose of cell tracking. These particles are biocompatible, non-toxic and act as excellent MRI contrast agents. This review will explore recent advances and issues in stem cell tracking and molecular imaging in relation to the IVD.

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300937/pdf/WJSC-7-65.pdf

U2 - 10.4252/wjsc.v7.i1.65

DO - 10.4252/wjsc.v7.i1.65

M3 - Article

VL - 7

SP - 65

EP - 74

JO - World Journal of Stem Cells

JF - World Journal of Stem Cells

SN - 1948-0210

IS - 1

ER -