Meropenem and meropenem-vaborbactam

Anton Y. Peleg, Patrick N.A. Harris

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Meropenem is a broad-spectrum parenteral carbapenem with antimicrobial activity against a wide range of Gramnegative and Gram-positive bacteria, including anaerobes. As a consequence of emerging multidrug resistance, especially in Gram-negative organisms, the clinical reliance on meropenem and other carbapenems increased after their introduction, especially in the intensive care unit setting. However, in recent years, resistance to carbapenems has emerged in Enterobacteriaceae and other Gram-negative bacilli. Of particular concern has been the acquisition of carbapenemase genes in major pathogens such as Escherichia coli and Klebsiella pneumoniae, with subsequent rapid dissemination across the world (Nordmann et al., 2011). This has provided a major challenge to our reliance on this useful antibiotic class for treating resistant Gram-negative organisms.

Original languageEnglish
Title of host publicationKucers the Use of Antibiotics
Subtitle of host publicationA Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs
EditorsM. Lindsay Grayson
Place of PublicationBoca Raton FL USA
PublisherCRC Press
Chapter38
Pages697-722
Number of pages26
Edition7th
ISBN (Electronic)9781498747967
ISBN (Print)9781498747950
Publication statusPublished - 2 Oct 2017

Cite this

Peleg, A. Y., & Harris, P. N. A. (2017). Meropenem and meropenem-vaborbactam. In M. L. Grayson (Ed.), Kucers the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs (7th ed., pp. 697-722). CRC Press.