Menstruation and endometrial repair

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Abstract

Menstruation is the process by which the functionalis layer of the endometrium is shed and restored during each menstrual cycle in women, without scarring or loss of function. The trigger for menstruation is withdrawal of hormonal support in a nonconception cycle, which induces highly controlled inflammatory mechanisms starting with influx and activation of specific leukocyte subsets and release of bioactive mediators, including degradative enzymes. Tissue breakdown and repair occur simultaneously in different/adjacent areas of the tissue. Re-epithelialization rapidly covers the degraded surface, independently of hormone (estrogen) support: full regeneration of the endometrial functionalis follows with estrogen support during the ensuing proliferative phase
Original languageEnglish
Title of host publicationEncyclopedia of Reproduction
EditorsMichael K. Skinner
PublisherAcademic Press
Pages320-325
Number of pages6
Edition2nd
ISBN (Electronic)9780128151457
DOIs
Publication statusPublished - 2018

Cite this

Salamonsen, L. A., & Evans, J. (2018). Menstruation and endometrial repair. In M. K. Skinner (Ed.), Encyclopedia of Reproduction (2nd ed., pp. 320-325). Academic Press. https://doi.org/10.1016/B978-0-12-801238-3.64653-6