Membrane nanodomains: Contribution of curvature and interaction with proteins and cytoskeleton

Senthil Arumugam, Patricia Bassereau

Research output: Contribution to journalReview ArticleResearchpeer-review

19 Citations (Scopus)

Abstract

The understanding of lipid membranes and their organization has undergone significant development with better techniques and therefore more resolved experiments. Many new factors and organizing principles have been discovered, and interplay between these factors is expected to result in rich functional behaviours. The major factors regulating the lateral membrane heterogeneity, apart from the well-studied phase separation, are cytoskeleton pinning, clustering of lipids and curvature. These factors are effective means to create membrane domains that provide rich biological functionality. We review the recent advances and concepts of membrane heterogeneity organization by curvature, cytoskeleton and clustering proteins.

Original languageEnglish
Article number9
Pages (from-to)109-119
Number of pages11
JournalEssays in Biochemistry
Volume57
DOIs
Publication statusPublished - May 2015
Externally publishedYes

Keywords

  • Curvature
  • Cytoskeletal pinning
  • Heterogeneity
  • Membrane
  • Phase transition
  • Phosphoinositide

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