During the last two decades, understanding of the aging process has experienced important advances. Discoveries like the roles of IGF1/insulin-like signaling, complex I oxygen radical generation, the role of membrane fatty acid unsaturation, accumulation of somatic mutations in mitochondrial DNA, the capacity of single-gene knockout animal models to increase mammalian longevity, or sex-related differences, have increased our knowledge concerning the main determinants of animal longevity including that of complex multicellular animal models similar to humans. Many of these discoveries have been appropriately covered in international scientific meetings and high-quality reviews some of which have been written by the coauthors of this book. Excellent books on aging have been also published during this time period. However, no book exists that comprehensively gathers all these advancements in the same volume, making it available to students, specialists and researchers of the different involved specialties. The aims of this book are various. On the one hand it tries to provide an up-to date text that includes the recent advances in the area of aging and its relationship to oxidative stress. The subjects included cannot be a complete account of this huge area of scientific research. Instead, they correspond to a selection of key aspects that seem to be important for the determination of animal and human longevity. The large number of references given in the whole book will also allow a more extensive coverage of the subjects to the interested reader. On the other hand, the book also tries to give a connected picture of the determinants of the aging process since the subjects have been selected giving particular attention to key aspects and new developments that seem to be important for the determination of animal longevity. To no surprise, many of them connect in one way or the other with the role of oxygen free radicals in cells and their activities and effects. Finally, we have tried to produce a work that can be easily understood by people with different backgrounds, including pre- and post-doctoral fellows, experienced researchers, and specialists from different disciplines including biologists, biochemists, molecular biologists, chemists, and people related to the areas of oxidative stress and aging. Finally, our gratitude goes to the authors that made possible this book. Both the timeliness and the high quality of their contributions made this book exceptional. Our special thanks also go to the Research Signpost for their long-standing support and patience. We hope that this book can constitute a significant contribution to further developments in the fascinating field concerned with the ultimate basic causes of aging and longevity.
|Title of host publication||Longevity, mitochondria and oxygen free radicals|
|Editors||R Pamplona, G Barja|
|Place of Publication||USA|
|Pages||79 - 94|
|Number of pages||16|
|Publication status||Published - 2010|