Melt-in-mouth pellets of fexofenadine hydrochloride using crospovidone as an extrusion-spheronisation aid

Satishkumar P. Jain, Dharmini C. Mehta, Sejal P. Shah, Pirthi Pal Singh, Purnima D. Amin

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20 Citations (Scopus)


Microcrystalline cellulose (MCC) is well established as an extrusion spheronisation aid for the preparation of pellets. Crospovidone (Polyplasdone® XL-10) is compared with microcrystalline cellulose for the preparation of melt-in-mouth pellets. Taste-masked fexofenadine hydrochloride was incorporated in the melt-in-mouth formulation. Crospovidone was found to be well suited as extrusion-spheronisation aid for the preparation of melt-in-mouth pellets. The great advantage of crospovidone is, however, the disintegrating properties of the pellets after only a short time of exposure to liquid. Crospovidone was successfully employed as an extrusion-spheronisation aid to produce melt-in-mouth pellets obviating the need of a traditional extrusion-spheronisation aid, MCC. Dual properties of Crospovidone were explored viz. as an extrusion-spheronisation aid and a disintegrant.

Original languageEnglish
Pages (from-to)917-923
Number of pages7
JournalAAPS PharmSciTech
Issue number2
Publication statusPublished - Jun 2010
Externally publishedYes


  • Crospovidone (Polyplasdone® XL-10)
  • Fexofenadine hydrochloride
  • Ion exchange resin
  • Melt-in-mouth pellets
  • Microcrystalline cellulose
  • Taste masking

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