TY - JOUR
T1 - Melittin, a Potential Natural Toxin of Crude Bee Venom
T2 - Probable Future Arsenal in the Treatment of Diabetes Mellitus
AU - Hossen, Md Sakib
AU - Gan, Siew Hua
AU - Khalil, Md Ibrahim
N1 - Publisher Copyright:
© 2017 Md. Sakib Hossen et al.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/7/12
Y1 - 2017/7/12
N2 - Since diabetes mellitus (DM) is one of the most common and serious endocrine metabolic disorders, it is important to elucidate novel antidiabetic therapeutic agents from various sources, including natural products. Bee venom (BV) is a complex mixture of proteins, peptides, and low molecular components, and melittin is the main constituent. Melittin is a peptide consisting of 26 amino acids with the sequence GIGAVLKVLTTGLPALISWIKRKRQQ. It has several important biological effects and has a relatively low toxicity. Recent studies using animal models have confirmed that melittin has significant glucose and lipid lowering activities by acting on several mechanistic pathways. The main antidiabetic activity of melittin is increasing insulin secretion via depolarization of pancreatic β-cells. Other possible mechanisms may involve stimulation of phospholipase A2, increase of glucose uptake, improving lipid profile, and/or reduction of inflammation. This review summarizes the various sources, proteomics, biological roles, adverse effects, and medical applications of melittin and its mechanism of action in combating DM.
AB - Since diabetes mellitus (DM) is one of the most common and serious endocrine metabolic disorders, it is important to elucidate novel antidiabetic therapeutic agents from various sources, including natural products. Bee venom (BV) is a complex mixture of proteins, peptides, and low molecular components, and melittin is the main constituent. Melittin is a peptide consisting of 26 amino acids with the sequence GIGAVLKVLTTGLPALISWIKRKRQQ. It has several important biological effects and has a relatively low toxicity. Recent studies using animal models have confirmed that melittin has significant glucose and lipid lowering activities by acting on several mechanistic pathways. The main antidiabetic activity of melittin is increasing insulin secretion via depolarization of pancreatic β-cells. Other possible mechanisms may involve stimulation of phospholipase A2, increase of glucose uptake, improving lipid profile, and/or reduction of inflammation. This review summarizes the various sources, proteomics, biological roles, adverse effects, and medical applications of melittin and its mechanism of action in combating DM.
UR - http://www.scopus.com/inward/record.url?scp=85026540075&partnerID=8YFLogxK
U2 - 10.1155/2017/4035626
DO - 10.1155/2017/4035626
M3 - Review Article
AN - SCOPUS:85026540075
VL - 2017
JO - Journal of Chemistry
JF - Journal of Chemistry
SN - 2090-9063
M1 - 4035626
ER -
