TY - JOUR
T1 - Melbourne Mobile Stroke Unit and Reperfusion Therapy
T2 - Greater Clinical Impact of Thrombectomy Than Thrombolysis
AU - Zhao, Henry
AU - Coote, Skye
AU - Easton, Damien
AU - Langenberg, Francesca
AU - Stephenson, Michael
AU - Smith, Karen
AU - Bernard, Stephen
AU - Cadilhac, Dominique A.
AU - Kim, Joosup
AU - Bladin, Christopher F.
AU - Churilov, Leonid
AU - Crompton, Douglas E.
AU - Dewey, Helen M.
AU - Sanders, Lauren M.
AU - Wijeratne, Tissa
AU - Cloud, Geoffrey
AU - Brooks, Duncan M.
AU - Asadi, Hamed
AU - Thijs, Vincent
AU - Chandra, Ronil V.
AU - Ma, Henry
AU - Desmond, Patricia M.
AU - Dowling, Richard J.
AU - Mitchell, Peter J.
AU - Yassi, Nawaf
AU - Yan, Bernard
AU - Campbell, Bruce C.V.
AU - Parsons, Mark W.
AU - Donnan, Geoffrey A.
AU - Davis, Stephen M.
PY - 2020/3
Y1 - 2020/3
N2 - Background and Purpose- Mobile stroke units (MSUs) are increasingly used worldwide to provide prehospital triage and treatment. The benefits of MSUs in giving earlier thrombolysis have been well established, but the impacts of MSUs on endovascular thrombectomy (EVT) and effect on disability avoidance are largely unknown. We aimed to determine the clinical impact and disability reduction for reperfusion therapies in the first operational year of the Melbourne MSU. Methods- Treatment time metrics for MSU patients receiving reperfusion therapy were compared with control patients presenting to metropolitan Melbourne stroke units via standard ambulance within MSU operating hours. The primary outcome was median time difference in first ambulance dispatch to treatment modeled using quantile regression analysis. Time savings were subsequently converted to disability-adjusted life years avoided using published estimates. Results- In the first 365-day operation of the Melbourne MSU, prehospital thrombolysis was administered to 100 patients (mean age, 73.8 years; 62% men). The median time savings per MSU patient, compared with the control cohort, was 26 minutes (P<0.001) for dispatch to hospital arrival and 15 minutes (P<0.001) for hospital arrival to thrombolysis. The calculated overall time saving from dispatch to thrombolysis was 42.5 minutes (95% CI, 36.0-49.0). In the same period, 41 MSU patients received EVT (mean age, 76 years; 61% men) with median dispatch-to-treatment time saving of 51 minutes ([95% CI, 30.1-71.9], P<0.001). This included a median time saving of 17 minutes ([95% CI, 7.6-26.4], P=0.001) for EVT hospital arrival to arterial puncture for MSU patients. Estimated median disability-adjusted life years saved through earlier provision of reperfusion therapies were 20.9 for thrombolysis and 24.6 for EVT. Conclusions- The Melbourne MSU substantially reduced time to reperfusion therapies, with the greatest estimated disability avoidance driven by the more powerful impact of earlier EVT. These findings highlight the benefits of prehospital notification and direct triage to EVT centers with facilitated workflow on arrival by the MSU.
AB - Background and Purpose- Mobile stroke units (MSUs) are increasingly used worldwide to provide prehospital triage and treatment. The benefits of MSUs in giving earlier thrombolysis have been well established, but the impacts of MSUs on endovascular thrombectomy (EVT) and effect on disability avoidance are largely unknown. We aimed to determine the clinical impact and disability reduction for reperfusion therapies in the first operational year of the Melbourne MSU. Methods- Treatment time metrics for MSU patients receiving reperfusion therapy were compared with control patients presenting to metropolitan Melbourne stroke units via standard ambulance within MSU operating hours. The primary outcome was median time difference in first ambulance dispatch to treatment modeled using quantile regression analysis. Time savings were subsequently converted to disability-adjusted life years avoided using published estimates. Results- In the first 365-day operation of the Melbourne MSU, prehospital thrombolysis was administered to 100 patients (mean age, 73.8 years; 62% men). The median time savings per MSU patient, compared with the control cohort, was 26 minutes (P<0.001) for dispatch to hospital arrival and 15 minutes (P<0.001) for hospital arrival to thrombolysis. The calculated overall time saving from dispatch to thrombolysis was 42.5 minutes (95% CI, 36.0-49.0). In the same period, 41 MSU patients received EVT (mean age, 76 years; 61% men) with median dispatch-to-treatment time saving of 51 minutes ([95% CI, 30.1-71.9], P<0.001). This included a median time saving of 17 minutes ([95% CI, 7.6-26.4], P=0.001) for EVT hospital arrival to arterial puncture for MSU patients. Estimated median disability-adjusted life years saved through earlier provision of reperfusion therapies were 20.9 for thrombolysis and 24.6 for EVT. Conclusions- The Melbourne MSU substantially reduced time to reperfusion therapies, with the greatest estimated disability avoidance driven by the more powerful impact of earlier EVT. These findings highlight the benefits of prehospital notification and direct triage to EVT centers with facilitated workflow on arrival by the MSU.
KW - aged
KW - hospitals
KW - humans
KW - stroke
KW - workflow
UR - http://www.scopus.com/inward/record.url?scp=85081110541&partnerID=8YFLogxK
U2 - 10.1161/STROKEAHA.119.027843
DO - 10.1161/STROKEAHA.119.027843
M3 - Article
C2 - 32078483
AN - SCOPUS:85081110541
SN - 0039-2499
VL - 51
SP - 922
EP - 930
JO - Stroke
JF - Stroke
IS - 3
ER -