Melatonin attenuates colistin-induced nephrotoxicity in rats

Jumana Yousef; Gong Chen; Prudence Hill; Roger Nation; Jian Li

doi:10.1128/AAC.00328-11

Melatonin attenuates colistin-induced nephrotoxicity in rats

Jumana Yousef, Gong Chen, Prudence Hill, Roger Nation, Jian Li

Research output: Contribution to journal › Article › Research › peer-review

109 Citations (Scopus)

Abstract

Colistin-induced nephrotoxicity is a dose-limiting adverse effect when colistin is used against Gram-negative pathogens. This study examined the nephroprotective effect of melatonin against colistin in rats.

Original language	English
Pages (from-to)	4044 - 4049
Number of pages	6
Journal	Antimicrobial Agents and Chemotherapy
Volume	55
Issue number	9
DOIs	https://doi.org/10.1128/AAC.00328-11
Publication status	Published - 2011

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10.1128/AAC.00328-11

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title = "Melatonin attenuates colistin-induced nephrotoxicity in rats",

abstract = "Colistin-induced nephrotoxicity is a dose-limiting adverse effect when colistin is used against Gram-negative pathogens. This study examined the nephroprotective effect of melatonin against colistin in rats.",

author = "Jumana Yousef and Gong Chen and Prudence Hill and Roger Nation and Jian Li",

year = "2011",

doi = "10.1128/AAC.00328-11",

language = "English",

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journal = "Antimicrobial Agents and Chemotherapy",

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AU - Yousef, Jumana

AU - Chen, Gong

AU - Hill, Prudence

AU - Nation, Roger

AU - Li, Jian

PY - 2011

Y1 - 2011

N2 - Colistin-induced nephrotoxicity is a dose-limiting adverse effect when colistin is used against Gram-negative pathogens. This study examined the nephroprotective effect of melatonin against colistin in rats.

AB - Colistin-induced nephrotoxicity is a dose-limiting adverse effect when colistin is used against Gram-negative pathogens. This study examined the nephroprotective effect of melatonin against colistin in rats.

UR - http://aac.asm.org/content/55/9/4044

U2 - 10.1128/AAC.00328-11

DO - 10.1128/AAC.00328-11

M3 - Article

C2 - 21709095

SN - 0066-4804

VL - 55

SP - 4044

EP - 4049

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 9

ER -

Melatonin attenuates colistin-induced nephrotoxicity in rats

Abstract

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Other files and links

Optimizing dosing of colistin for infections resistant to all other antibiotics.

Targeting MD hetero-resistant Gram-negatives: PK/PD for rational combinations.

Cite this

Melatonin attenuates colistin-induced nephrotoxicity in rats

Abstract

Access to Document

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Projects

Optimizing dosing of colistin for infections resistant to all other antibiotics.

Targeting MD hetero-resistant Gram-negatives: PK/PD for rational combinations.

Cite this