Melatonin as an oncostatic agent: Review of the modulation of tumor microenvironment and overcoming multidrug resistance

Niloufar Targhazeh, Karla J. Hutt, Amy L. Winship, Russel Reiter, Bahman Yousefi

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)


Multi drug resistance (MDR) generally limits the efficacy of chemotherapy in cancer patients and can be categorized into primary or acquired resistance. Melatonin (MLT), a lipophilic hormone released from pineal gland, is a molecule with oncostatic effects. Here, we will briefly review the contribution of different microenvironmental components including fibroblasts, immune and inflammatory cells, stem cells and vascular endothelial cells in tumor initiation, progression and development. Then, the mechanisms by which MLT can potentially affect these elements and regulate drug resistance will be presented. Finally, we will explain how different studies have used novel strategies incorporating MLT to suppress cancer resistance against therapeutics.

Original languageEnglish
Pages (from-to)71-84
Number of pages14
Publication statusPublished - Nov 2022


  • Cancer
  • Chemoresistance
  • Drug resistance
  • Hormone
  • Immune system
  • Stem cells

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