Abstract
Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.
| Original language | English |
|---|---|
| Pages (from-to) | 845-847 |
| Number of pages | 3 |
| Journal | Nature Neuroscience |
| Volume | 16 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - May 2013 |
| Externally published | Yes |
Cite this
}
Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume. / Conductier, Grégory; Brau, Frédéric; Viola, Angèle; Langlet, Fanny; Ramkumar, Navean; Dehouck, Bénédicte; Lemaire, Thibault; Chapot, Raphaël; Lucas, Laurianne; Rovère, Carole; Maitre, Priscilla; Hosseiny, Salma; Petit-Paitel, Agnès; Adamantidis, Antoine; Lakaye, Bernard; Risold, Pierre Yves; Prévot, Vincent; Meste, Olivier; Nahon, Jean-Louis; Guyon, Alice.
In: Nature Neuroscience, Vol. 16, No. 7, 05.2013, p. 845-847.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume
AU - Conductier, Grégory
AU - Brau, Frédéric
AU - Viola, Angèle
AU - Langlet, Fanny
AU - Ramkumar, Navean
AU - Dehouck, Bénédicte
AU - Lemaire, Thibault
AU - Chapot, Raphaël
AU - Lucas, Laurianne
AU - Rovère, Carole
AU - Maitre, Priscilla
AU - Hosseiny, Salma
AU - Petit-Paitel, Agnès
AU - Adamantidis, Antoine
AU - Lakaye, Bernard
AU - Risold, Pierre Yves
AU - Prévot, Vincent
AU - Meste, Olivier
AU - Nahon, Jean-Louis
AU - Guyon, Alice
PY - 2013/5
Y1 - 2013/5
N2 - Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.
AB - Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.
UR - http://www.scopus.com/inward/record.url?scp=84891689207&partnerID=8YFLogxK
U2 - 10.1038/nn.3401
DO - 10.1038/nn.3401
M3 - Article
AN - SCOPUS:84891689207
VL - 16
SP - 845
EP - 847
JO - Nature Neuroscience
JF - Nature Neuroscience
SN - 1097-6256
IS - 7
ER -