Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume

Grégory Conductier; Frédéric Brau; Angèle Viola; Fanny Langlet; Navean Ramkumar; Bénédicte Dehouck; Thibault Lemaire; Raphaël Chapot; Laurianne Lucas; Carole Rovère; Priscilla Maitre; Salma Hosseiny; Agnès Petit-Paitel; Antoine Adamantidis; Bernard Lakaye; Pierre Yves Risold; Vincent Prévot; Olivier Meste; Jean-Louis Nahon; Alice Guyon

doi:10.1038/nn.3401

Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume

Grégory Conductier, Frédéric Brau, Angèle Viola, Fanny Langlet, Navean Ramkumar, Bénédicte Dehouck, Thibault Lemaire, Raphaël Chapot, Laurianne Lucas, Carole Rovère, Priscilla Maitre, Salma Hosseiny, Agnès Petit-Paitel, Antoine Adamantidis, Bernard Lakaye, Pierre Yves Risold, Vincent Prévot, Olivier Meste, Jean-Louis Nahon, Alice Guyon

Research output: Contribution to journal › Article › Research › peer-review

43 Citations (Scopus)

Abstract

Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.

Original language	English
Pages (from-to)	845-847
Number of pages	3
Journal	Nature Neuroscience
Volume	16
Issue number	7
DOIs	https://doi.org/10.1038/nn.3401
Publication status	Published - May 2013
Externally published	Yes

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10.1038/nn.3401

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Conductier, G., Brau, F., Viola, A., Langlet, F., Ramkumar, N., Dehouck, B., Lemaire, T., Chapot, R., Lucas, L., Rovère, C., Maitre, P., Hosseiny, S., Petit-Paitel, A., Adamantidis, A., Lakaye, B., Risold, P. Y., Prévot, V., Meste, O., Nahon, J-L., & Guyon, A. (2013). Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume. Nature Neuroscience, 16(7), 845-847. https://doi.org/10.1038/nn.3401

Conductier, Grégory ; Brau, Frédéric ; Viola, Angèle ; Langlet, Fanny ; Ramkumar, Navean ; Dehouck, Bénédicte ; Lemaire, Thibault ; Chapot, Raphaël ; Lucas, Laurianne ; Rovère, Carole ; Maitre, Priscilla ; Hosseiny, Salma ; Petit-Paitel, Agnès ; Adamantidis, Antoine ; Lakaye, Bernard ; Risold, Pierre Yves ; Prévot, Vincent ; Meste, Olivier ; Nahon, Jean-Louis ; Guyon, Alice. / Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume. In: Nature Neuroscience. 2013 ; Vol. 16, No. 7. pp. 845-847.

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title = "Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume",

abstract = "Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.",

author = "Gr{\'e}gory Conductier and Fr{\'e}d{\'e}ric Brau and Ang{\`e}le Viola and Fanny Langlet and Navean Ramkumar and B{\'e}n{\'e}dicte Dehouck and Thibault Lemaire and Rapha{\"e}l Chapot and Laurianne Lucas and Carole Rov{\`e}re and Priscilla Maitre and Salma Hosseiny and Agn{\`e}s Petit-Paitel and Antoine Adamantidis and Bernard Lakaye and Risold, {Pierre Yves} and Vincent Pr{\'e}vot and Olivier Meste and Jean-Louis Nahon and Alice Guyon",

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Conductier, G, Brau, F, Viola, A, Langlet, F, Ramkumar, N, Dehouck, B, Lemaire, T, Chapot, R, Lucas, L, Rovère, C, Maitre, P, Hosseiny, S, Petit-Paitel, A, Adamantidis, A, Lakaye, B, Risold, PY, Prévot, V, Meste, O, Nahon, J-L & Guyon, A 2013, 'Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume', Nature Neuroscience, vol. 16, no. 7, pp. 845-847. https://doi.org/10.1038/nn.3401

Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume. / Conductier, Grégory; Brau, Frédéric; Viola, Angèle; Langlet, Fanny; Ramkumar, Navean; Dehouck, Bénédicte; Lemaire, Thibault; Chapot, Raphaël; Lucas, Laurianne; Rovère, Carole; Maitre, Priscilla; Hosseiny, Salma; Petit-Paitel, Agnès; Adamantidis, Antoine; Lakaye, Bernard; Risold, Pierre Yves; Prévot, Vincent; Meste, Olivier; Nahon, Jean-Louis; Guyon, Alice.

In: Nature Neuroscience, Vol. 16, No. 7, 05.2013, p. 845-847.

Research output: Contribution to journal › Article › Research › peer-review

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