Abstract
Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.
Original language | English |
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Pages (from-to) | 845-847 |
Number of pages | 3 |
Journal | Nature Neuroscience |
Volume | 16 |
Issue number | 7 |
DOIs | |
Publication status | Published - May 2013 |
Externally published | Yes |