Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume

Grégory Conductier, Frédéric Brau, Angèle Viola, Fanny Langlet, Navean Ramkumar, Bénédicte Dehouck, Thibault Lemaire, Raphaël Chapot, Laurianne Lucas, Carole Rovère, Priscilla Maitre, Salma Hosseiny, Agnès Petit-Paitel, Antoine Adamantidis, Bernard Lakaye, Pierre Yves Risold, Vincent Prévot, Olivier Meste, Jean-Louis Nahon, Alice Guyon

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43 Citations (Scopus)

Abstract

Ependymal cell cilia help move cerebrospinal fluid through the cerebral ventricles, but the regulation of their beat frequency remains unclear. Using in vitro, high-speed video microscopy and in vivo magnetic resonance imaging in mice, we found that the metabolic peptide melanin-concentrating hormone (MCH) positively controlled cilia beat frequency, specifically in the ventral third ventricle, whereas a lack of MCH receptor provoked a ventricular size increase.

Original languageEnglish
Pages (from-to)845-847
Number of pages3
JournalNature Neuroscience
Volume16
Issue number7
DOIs
Publication statusPublished - May 2013
Externally publishedYes

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