TY - JOUR
T1 - Mechanistic insight into the function of the microbiome in lung diseases
AU - Ubags, Niki D.J.
AU - Marsland, Benjamin J.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - The lung harbours a diverse array of microbes whose dynamic composition is influenced by both host and environmental factors. Thus far, most studies have described the microbial composition of healthy or diseased lungs and provided an overview of the differences between topographical locations within the respiratory tract. However, insight into the functional mechanisms underlying host-microbe interactions and how they might drive lung health and disease are limited. This review provides an overview of the current mechanistic understanding of the microbiome, crosstalk between tissue compartments, and its involvement in respiratory diseases.
AB - The lung harbours a diverse array of microbes whose dynamic composition is influenced by both host and environmental factors. Thus far, most studies have described the microbial composition of healthy or diseased lungs and provided an overview of the differences between topographical locations within the respiratory tract. However, insight into the functional mechanisms underlying host-microbe interactions and how they might drive lung health and disease are limited. This review provides an overview of the current mechanistic understanding of the microbiome, crosstalk between tissue compartments, and its involvement in respiratory diseases.
UR - http://www.scopus.com/inward/record.url?scp=85030030840&partnerID=8YFLogxK
U2 - 10.1183/13993003.02467-2016
DO - 10.1183/13993003.02467-2016
M3 - Article
C2 - 28893867
AN - SCOPUS:85030030840
SN - 0903-1936
VL - 50
JO - European Respiratory Journal
JF - European Respiratory Journal
IS - 3
M1 - 02467
ER -