Mechanistic insight into how Shh patterns the vertebrate limb

Edwina McGlinn, Clifford Tabin

Research output: Contribution to journalArticleOther

75 Citations (Scopus)

Abstract

The hands and feet of a newborn baby are a beautiful reminder of the complexity of embryonic patterning. Classical studies on how these structures form have led to a theoretical framework for understanding, in general, how discrete groups of cells can instruct differential fates across a wider field through the action of long-range signals. The discovery just more than a decade ago that localized expression of Sonic hedgehog (Shh) differentially patterns structures across the limb field, resulting in digits with unique characteristics, provided a starting point for readdressing these models at a molecular level. Current research has revealed unexpected complexity in how a gradient of Shh activity is both established and received, prompting re-evaluation of the nature of patterning mechanisms within the limb.
Original languageEnglish
Pages (from-to)426 - 432
Number of pages7
JournalCurrent Opinion in Genetics and Development
Volume16
Issue number4
DOIs
Publication statusPublished - 2006
Externally publishedYes

Cite this

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abstract = "The hands and feet of a newborn baby are a beautiful reminder of the complexity of embryonic patterning. Classical studies on how these structures form have led to a theoretical framework for understanding, in general, how discrete groups of cells can instruct differential fates across a wider field through the action of long-range signals. The discovery just more than a decade ago that localized expression of Sonic hedgehog (Shh) differentially patterns structures across the limb field, resulting in digits with unique characteristics, provided a starting point for readdressing these models at a molecular level. Current research has revealed unexpected complexity in how a gradient of Shh activity is both established and received, prompting re-evaluation of the nature of patterning mechanisms within the limb.",
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Mechanistic insight into how Shh patterns the vertebrate limb. / McGlinn, Edwina; Tabin, Clifford.

In: Current Opinion in Genetics and Development, Vol. 16, No. 4, 2006, p. 426 - 432.

Research output: Contribution to journalArticleOther

TY - JOUR

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AU - McGlinn, Edwina

AU - Tabin, Clifford

PY - 2006

Y1 - 2006

N2 - The hands and feet of a newborn baby are a beautiful reminder of the complexity of embryonic patterning. Classical studies on how these structures form have led to a theoretical framework for understanding, in general, how discrete groups of cells can instruct differential fates across a wider field through the action of long-range signals. The discovery just more than a decade ago that localized expression of Sonic hedgehog (Shh) differentially patterns structures across the limb field, resulting in digits with unique characteristics, provided a starting point for readdressing these models at a molecular level. Current research has revealed unexpected complexity in how a gradient of Shh activity is both established and received, prompting re-evaluation of the nature of patterning mechanisms within the limb.

AB - The hands and feet of a newborn baby are a beautiful reminder of the complexity of embryonic patterning. Classical studies on how these structures form have led to a theoretical framework for understanding, in general, how discrete groups of cells can instruct differential fates across a wider field through the action of long-range signals. The discovery just more than a decade ago that localized expression of Sonic hedgehog (Shh) differentially patterns structures across the limb field, resulting in digits with unique characteristics, provided a starting point for readdressing these models at a molecular level. Current research has revealed unexpected complexity in how a gradient of Shh activity is both established and received, prompting re-evaluation of the nature of patterning mechanisms within the limb.

UR - http://www.ncbi.nlm.nih.gov/pubmed/16806898

U2 - 10.1016/j.gde.2006.06.013

DO - 10.1016/j.gde.2006.06.013

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VL - 16

SP - 426

EP - 432

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

SN - 0959-437X

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