Mechanisms of regulation of the chemokine-receptor network

Martin J Stone, Jenni A. Hayward, Cheng Huang, Zil E. Huma, Julie Sanchez

Research output: Contribution to journalReview ArticleResearchpeer-review

78 Citations (Scopus)

Abstract

The interactions of chemokines with their G protein-coupled receptors promote the migration of leukocytes during normal immune function and as a key aspect of the inflammatory response to tissue injury or infection. This review summarizes the major cellular and biochemical mechanisms by which the interactions of chemokines with chemokine receptors are regulated, including: selective and competitive binding interactions; genetic polymorphisms; mRNA splice variation; variation of expression, degradation and localization; down-regulation by atypical (decoy) receptors; interactions with cell-surface glycosaminoglycans; post-translational modifications; oligomerization; alternative signaling responses; and binding to natural or pharmacological inhibitors.

Original languageEnglish
Article number342
Number of pages33
JournalInternational Journal of Molecular Sciences
Volume18
Issue number2
DOIs
Publication statusPublished - 7 Feb 2017

Keywords

  • Binding
  • Chemokine
  • Chemokine receptor
  • Expression
  • Glycosaminoglycan
  • Inhibitor
  • Oligomerization
  • Post-translational modification
  • Regulation
  • Signaling

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