Mechanisms of receptor shedding in platelets

Samantha J. Montague, Robert K. Andrews, Elizabeth E. Gardiner

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

The ability to upregulate and downregulate surface-exposed proteins and receptors is a powerful process that allows a cell to instantly respond to its microenvironment. In particular, mobile cells in the bloodstream must rapidly react to conditions where infection or inflammation are detected, and become proadhesive, phagocytic, and/or procoagulant. Platelets are one such blood cell that must rapidly acquire and manage proadhesive and procoagulant properties in order to execute their primary function in hemostasis. The regulation of platelet membrane properties is achieved via several mechanisms, one of which involves the controlled metalloproteolytic release of adhesion receptors and other proteins from the platelet surface. Proteolysis effectively lowers receptor density and reduces the reactivity of platelets, and is a mechanism to control robust platelet activation. Recent research has also established clear links between levels of platelet receptors and platelet lifespan. In this review, we will discuss the current knowledge of metalloproteolytic receptor regulation in the vasculature with emphasis on the platelet receptor system to highlight how receptor density can influence both platelet function and platelet survival.

Original languageEnglish
Pages (from-to)2535-2545
Number of pages11
JournalBlood
Volume132
Issue number24
DOIs
Publication statusPublished - 13 Dec 2018

Cite this

Montague, Samantha J. ; Andrews, Robert K. ; Gardiner, Elizabeth E. / Mechanisms of receptor shedding in platelets. In: Blood. 2018 ; Vol. 132, No. 24. pp. 2535-2545.
@article{69e9b736011745988e7962412aef7540,
title = "Mechanisms of receptor shedding in platelets",
abstract = "The ability to upregulate and downregulate surface-exposed proteins and receptors is a powerful process that allows a cell to instantly respond to its microenvironment. In particular, mobile cells in the bloodstream must rapidly react to conditions where infection or inflammation are detected, and become proadhesive, phagocytic, and/or procoagulant. Platelets are one such blood cell that must rapidly acquire and manage proadhesive and procoagulant properties in order to execute their primary function in hemostasis. The regulation of platelet membrane properties is achieved via several mechanisms, one of which involves the controlled metalloproteolytic release of adhesion receptors and other proteins from the platelet surface. Proteolysis effectively lowers receptor density and reduces the reactivity of platelets, and is a mechanism to control robust platelet activation. Recent research has also established clear links between levels of platelet receptors and platelet lifespan. In this review, we will discuss the current knowledge of metalloproteolytic receptor regulation in the vasculature with emphasis on the platelet receptor system to highlight how receptor density can influence both platelet function and platelet survival.",
author = "Montague, {Samantha J.} and Andrews, {Robert K.} and Gardiner, {Elizabeth E.}",
year = "2018",
month = "12",
day = "13",
doi = "10.1182/blood-2018-03-742668",
language = "English",
volume = "132",
pages = "2535--2545",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "24",

}

Montague, SJ, Andrews, RK & Gardiner, EE 2018, 'Mechanisms of receptor shedding in platelets' Blood, vol. 132, no. 24, pp. 2535-2545. https://doi.org/10.1182/blood-2018-03-742668

Mechanisms of receptor shedding in platelets. / Montague, Samantha J.; Andrews, Robert K.; Gardiner, Elizabeth E.

In: Blood, Vol. 132, No. 24, 13.12.2018, p. 2535-2545.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Mechanisms of receptor shedding in platelets

AU - Montague, Samantha J.

AU - Andrews, Robert K.

AU - Gardiner, Elizabeth E.

PY - 2018/12/13

Y1 - 2018/12/13

N2 - The ability to upregulate and downregulate surface-exposed proteins and receptors is a powerful process that allows a cell to instantly respond to its microenvironment. In particular, mobile cells in the bloodstream must rapidly react to conditions where infection or inflammation are detected, and become proadhesive, phagocytic, and/or procoagulant. Platelets are one such blood cell that must rapidly acquire and manage proadhesive and procoagulant properties in order to execute their primary function in hemostasis. The regulation of platelet membrane properties is achieved via several mechanisms, one of which involves the controlled metalloproteolytic release of adhesion receptors and other proteins from the platelet surface. Proteolysis effectively lowers receptor density and reduces the reactivity of platelets, and is a mechanism to control robust platelet activation. Recent research has also established clear links between levels of platelet receptors and platelet lifespan. In this review, we will discuss the current knowledge of metalloproteolytic receptor regulation in the vasculature with emphasis on the platelet receptor system to highlight how receptor density can influence both platelet function and platelet survival.

AB - The ability to upregulate and downregulate surface-exposed proteins and receptors is a powerful process that allows a cell to instantly respond to its microenvironment. In particular, mobile cells in the bloodstream must rapidly react to conditions where infection or inflammation are detected, and become proadhesive, phagocytic, and/or procoagulant. Platelets are one such blood cell that must rapidly acquire and manage proadhesive and procoagulant properties in order to execute their primary function in hemostasis. The regulation of platelet membrane properties is achieved via several mechanisms, one of which involves the controlled metalloproteolytic release of adhesion receptors and other proteins from the platelet surface. Proteolysis effectively lowers receptor density and reduces the reactivity of platelets, and is a mechanism to control robust platelet activation. Recent research has also established clear links between levels of platelet receptors and platelet lifespan. In this review, we will discuss the current knowledge of metalloproteolytic receptor regulation in the vasculature with emphasis on the platelet receptor system to highlight how receptor density can influence both platelet function and platelet survival.

UR - http://www.scopus.com/inward/record.url?scp=85058611002&partnerID=8YFLogxK

U2 - 10.1182/blood-2018-03-742668

DO - 10.1182/blood-2018-03-742668

M3 - Review Article

VL - 132

SP - 2535

EP - 2545

JO - Blood

JF - Blood

SN - 0006-4971

IS - 24

ER -